1370528-70-3

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 70571-31-2 1-benzylpiperidine-2,4-dione 
• 182559-62-2 ethyl 3-[benzyl(3-ethoxy-3-oxopropyl)amino]-3-oxopropanoate 
• 23583-21-3 ethyl-3-benzylamino propionate 

Downstream Products

• 1433193-92-0 4-(2-aminophenyl)-1-benzyl-3-bromo-5,6-dihydropyridin-2(1H)-one 
• 1433193-93-1 1-benzyl-3-bromo-4-[2-(tritylamino)phenyl]-5,6-dihydropyridin-2(1H)-one 
• 1433193-94-2 4-(2-aminophenyl)-1-benzyl-3-(2-chlorophenyl)-5,6-dihydropyridin-2(1H)-one 
• 1433193-95-3 1-{2-[1-benzyl-5-(2-chlorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-4-yl]phenyl}-3-(4-methoxyphenyl)urea 
• 1433193-96-4 1-{2-[1-benzyl-5-(2-chlorophenyl)-6-oxo-1,2,3,6-tetrahydropyridin-4-yl]phenyl}-3-(4-methoxybenzyl)urea 
• 1433193-90-8 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one 
• 1433193-97-5 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxybenzyl)iminomethyleneaminophenyl]-5,6-dihydropyridin-2(1H)-one 
• 1433193-91-9 tert-butyl [2-(1-benzyl-6-oxo-1,2,3,6-tetrahydropyridin-4-yl)phenyl]carbamate 

Relevant academic research and scientific papers

Synthetic study of perophoramidine: Construction of pentacyclic core structure via SmI2-mediated reductive cyclization

An intramolecular SmI2-mediated reductive cyclization of carbodiimides and unsaturated lactams was applied to functionalized substrates bearing tetrasubstituted olefins. The reaction afforded arylated spiro-2-iminoindolines in high yield. Although the stereochemistry of the product was different from the desired one, the optimized palladium-catalyzed aryl amidination realized the isomerization and C-N bond formation in a single step and resulted in efficient construction of pentacyclic core of perophoramidine synthetically equivalent to the Rainier's intermediate.