143360-88-7

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-[2-(1-hexynyl)phenyl]-
• CAS NO: 143360-88-7
• Molecular Formula: C14H14F3NO
• Molecular Weight: 269.266
• Mol File: 143360-88-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-[2-(1-hexynyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-[2-(1-hexynyl)phenyl]-(143360-88-7)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-[2-(1-hexynyl)phenyl]-(143360-88-7)

Safety Data

• Hazardous Substances Data: 143360-88-7(Hazardous Substances Data)

Upstream product

• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 693-02-7 hex-1-yne 

Downstream Products

• 619-44-3 methyl 4-iodobenzoate 
• 155335-09-4 2-n-butyl-3-(4-methoxybenzoyl)indole 
• 1224449-92-6 2-(2-butyl-1H-indol-3-yl)cyclohex-2-en-1-one 
• 143360-79-6 2-Butyl-3-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-1H-indole 
• 143360-80-9 2-Butyl-3-(4-phenyl-cyclohex-1-enyl)-1H-indole 
• 143360-78-5 2-butyl-3-(4-methoxy-phenyl)-1H-indole 

Relevant articles and documents

2-Substituted-3-acylindoles through the palladium-catalysed carbonylative cyclization of 2-alkynyltrifluoroacetanilides with aryl halides and vinyl triflates

The palladium-catalysed reaction of readily accessible 2- alkynyltrifluoroacetanilides with aryl halides and vinyl triflates under a carbon monoxide atmosphere (1 or 7 atm) and in the presence of potassium carbonate produces 2-substituted-3-acyl indoles in fair to good yield. The acidity of the nitrogen-hydrogen bond proved to be of primary importance for the success of the reaction. The methodology has been applied to the synthesis of pravadoline, a drug that shows analgesic activity against postoperative pain in man.