1433220-02-0Relevant articles and documents
Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes
Mavrynsky, Denys,Rahkila, Jani,Bandarra, Daniel,Martins, Soraia,Meireles, Margarida,Calhorda, Maria Jose,Kovacs, Ida J.,Zupko, Istvan,Haenninen, Mikko M.,Leino, Reko
, p. 3012 - 3017 (2013)
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.