143327-82-6Relevant articles and documents
Preparation and Reactions of Chiral Propargylic Amines
Hauske, James R.,Dorff, Peter,Julin, Susan,Martinelli, Gary,Bussolari, Jacqueline
, p. 3715 - 3716 (2007/10/02)
Exposure of chiral amino aldehydes (1) to dimethyl diazophosphonate (4) affords propargylic amines (2) of high optical purity.Chain extension of these intermediates is readily accomplished via hydrozirconation of the acetylene moiety and subsequent Ni(II) catalyzed Michael addition to a variety of Michael acceptors.