143329-89-9

Basic information

• Product Name: 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL
• Synonyms: 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL;α2,α6-Dimethyl-2,6-pyridinedimethanol,99%e.e.;1,1-(Pyridine-2,6-diyl)diethanol;α2,α6-Dimethyl-2,6-pyridinedimethanol
• CAS NO: 143329-89-9
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.20502
• Mol File: 143329-89-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL(143329-89-9)
• EPA Substance Registry System: 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL(143329-89-9)

Safety Data

• Hazardous Substances Data: 143329-89-9(Hazardous Substances Data)

Usage

Chemical structure

The compound consists of a pyridine ring with a 1-hydroxy-ethyl group attached at the 6th position and an ethanol moiety at the 2nd position.

Molecular weight

Approximately 167.21 g/mol

Functional groups

The compound contains a pyridine ring, an alcohol (hydroxyl) group, and an ether linkage.

Pharmacological applications

It is used in research as a potential drug molecule due to its ability to modulate specific biological pathways.

Therapeutic potential

The compound may have therapeutic potential in the treatment of various diseases and disorders, although further research is needed to fully understand its pharmacological properties and potential applications.

Solubility

The compound is likely to be soluble in polar solvents such as water, methanol, and ethanol due to the presence of hydroxyl and ether functional groups.

Stability

The compound may be sensitive to oxidation and hydrolysis, as it contains alcohol and ether functional groups. It should be stored under appropriate conditions to maintain its stability.

Synonyms

The compound may be referred to by various names, such as 1-(6-(1-hydroxyethyl)pyridin-2-yl)ethanol, or by its IUPAC name.

Research focus

The compound is primarily studied in the context of its potential pharmacological properties and applications in the treatment of diseases and disorders.

Safety precautions

As with any chemical compound, appropriate safety measures should be taken when handling 1-(6-(1-HYDROXY-ETHYL)-PYRIDIN-2-YL)-ETHANOL, including the use of personal protective equipment (PPE) and proper disposal methods.

Regulatory status

The compound's regulatory status may vary depending on the country and its intended use. It is important to consult relevant guidelines and regulations when working with this compound.

Upstream product

• 1129-30-2 2,6-Diacetylpyridine 

Downstream Products

• 1129-30-2 2,6-Diacetylpyridine 
• 143394-12-1 (R,S)-α,α'-dimethyl-2,6-pyridinedimethanol 
• 143329-86-6 (R,R)-α,α'-dimethyl-2,6-pyridinedimethanol 
• 143329-85-5 (R,R)-α,α'-dimethyl-2,6-pyridinedimethanol 
• 923931-01-5 2-{(R)-1-[(S)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine 
• 923931-03-7 2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine 
• 923930-94-3 2-{(S)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine 
• 923930-99-8 2-((R)-1-acetoxyethyl)-6-{(R)-1-[(S)-1-phenylethyl]aminoethyl}pyridine 
• 923931-00-4 2-((R)-1-acetoxyethyl)-6-{(R)-1-[(R)-1-phenylethyl]aminoethyl}pyridine 
• 923930-90-9 2-((R)-1-hydroxyethyl)-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine 
• 923930-91-0 2-((R)-1-hydroxyethyl)-6-{(S)-1-[(R)-1-phenylethyl]aminoethyl}pyridine 
• 935-28-4 2,6-diethylpyridine 

Relevant articles and documents

Hydrogenation of Carbonyl Derivatives with a Well-Defined Rhenium Precatalyst

The first efficient and general rhenium-catalyzed hydrogenation of carbonyl derivatives was developed. The key to the success of the reaction was the use of a well-defined rhenium complex bearing a tridentate diphosphinoamino ligand as the catalyst (0.5 mol %) at 70 °C in the presence of H2 (30 bar). The mechanism of the reaction was investigated by DFT(PBE0-D3) calculations.

Chemoenzymatic preparation of all the stereoisomers of 2-(1-hydroxyethyl)- and 2,6-bis(1-hydroxyethyl)pyridines and their acetates

Several lipases were tested for the enantiomerically selective acetylation of racemic 1-[6-(1-hydroxyethyl)-pyridin-2-yl]ethanone rac-2 to yield alcohol (S)-2 and acetate (R)-3. Acetylation of a diastereomeric mixture of racemic and meso-2,6-bis(1-hydroxy-ethyl)pyridine, rac/meso-4, with the most selective Novozym 435 lipase in vinyl acetate resulted in a mixture of enantiopure diol (S,S)-4, monoacetate (R,S)-5 and diacetate (R,R)-6. Hydrolysis of the mixture of racemic and meso-2,6-bis(1-acetoxyethyl)pyridine rac/meso-6 by the same enzyme gave the pure enantiomers of diol (R,R)-4, monoacetate (S,R)-5 and diacetate (S,S)-6. Using further chemical and enzymatic steps alcohol (R)-2, acetate (S)-3, (S,S)- and (R,R)-monoacetates (S,S)-5 and (R,R)-5, meso-4 and its acetate meso-6 were also prepared and characterized.

Synthesis of Some 2,6-Di- and 1,2,6-Trisubstituted -1,4-Dihydropyridines as Antimicrobial Agents

Reduction of 2,6-diacylpyridine (1) with amalgamated zinc in hydrochloric acid (Clemmensen reduction) and with zinc in formic or acetic acid gave rise to the formation of diethanol- (2) and/diethyl- (3) pyridines. Reduction of (1), (2) and (3) with sodium borohydride afforded the corresponding 1,4 dihydro-pyridines (4),(5) and (6), respectively. Acetylation of (4) and (5) gave triketone- (7) and ketodicarbinol- (8) derivatives, respectively, which were further reduced to the tricarbinol derivative (9). Antimicrobial evaluation of compounds (1-9) showed remarkable results when compared with four known antibiotics.