1129-30-2

Basic information

• Product Name: 2,6-Diacetylpyridine
• Synonyms: 2,6-DIACETYLPYRIDINE;1-(6-ACETYL-PYRIDIN-2-YL)-ETHANONE;pyridine-2,6-diacetyl;2,6-Diacetylpyridine 99%;2,6 Diacetylpyridine 99% min.;Ethanone, 1,1'-(2,6-pyridinediyl)bis-;2,6-Diacetylpyridine ,97%;1,1'-(2,6-Pyridinediyl)bisethanone
• CAS NO: 1129-30-2
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 214-442-9
• Product Categories: Pyridine;Pyridines derivates;Pyridines;C9 to C46;Heterocyclic Building Blocks;Building Blocks;C8 to C9;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 1129-30-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 79-82 °C(lit.)
• Boiling Point: 126 °C / 6mmHg
• Flash Point: 131.9 °C
• Appearance: White to off-white/Crystalline Needles or Powder
• Density: 1.2021 (rough estimate)
• Vapor Pressure: 0.00251mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.88±0.10(Predicted)
• Water Solubility: Soluble in water, chloroform, and DMSO.
• BRN: 118286
• CAS DataBase Reference: 2,6-Diacetylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Diacetylpyridine(1129-30-2)
• EPA Substance Registry System: 2,6-Diacetylpyridine(1129-30-2)

Safety Data

• Hazard Codes: Xi,F
• Statements: 36/37/38-15-10
• Safety Statements: 26-36-43-7/8
• WGK Germany: 3
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 1129-30-2(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystalline needles or powder

Uses

2,6-Diacetylpyridine is used as intermediate in organic synthesis. It is a precursor to ligands in coordination chemistry.

InChI:InChI=1/C9H9NO2/c1-6(11)8-4-3-5-9(10-8)7(2)12/h3-5H,1-2H3

Upstream product

• 15658-60-3 diethyl-2,6-pyridinedicarbonyl ester 
• 141-78-6 ethyl acetate 
• 67-56-1 methanol 
• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 935-28-4 2,6-diethylpyridine 
• 36763-33-4 N²,N²,N⁶,N⁶-tetraethyl-2,6-pyridinedicarboxamide 
• 676-58-4 methylmagnesium chloride 
• 3739-94-4 2,6-Pyridinedicarbonyl dichloride 
• 917-54-4 methyllithium 
• 5704-66-5 pyruvoyl chloride 
• 143329-89-9 α,α'-dihydroxy-1,3-diethylpyridine 

Downstream Products

• 85575-96-8 6,6''-diphenyl 2,2',6',2''-terpyridine 
• 81874-55-7 2,6-bis<2-<4-(methylthio)-6-phenyl>pyridinyl>pyridine 
• 121501-03-9 (3-Phenyl-propyl)-[1-(6-{1-[(E)-3-phenyl-propylimino]-ethyl}-pyridin-2-yl)-eth-(E)-ylidene]-amine 
• 132843-84-6 2,6-bis-<1-oxo-3-(p-tolyl)prop-2-enyl>pyridine 
• 132843-86-8 2,6-bis<3-(p-chlorophenyl)-1-oxoprop-2-enyl>pyridine 
• 851908-75-3 2,6-bis<3-(p-hydroxyphenyl)-1-oxoprop-2-enyl>pyridine 
• 73818-26-5 2,6-diacetylpyridine bis(benzoylhydrazone) 
• 76115-25-8 2,6-diacetylpyridine bis(salicyloylhydrazone) 
• 55137-80-9 2,6-bis{1-(phenylimino)ethyl}pyridine 
• 3882-42-6 2,6-bis-[1-(2-phenylhydrazono)ethyl]pyridine 
• 55137-81-0 2,6-bis[1-(benzylimino)ethyl]pyridine 
• 85127-21-5 2,6-diacetylpyridinebis(2-aminobenzoic acid hydrazone) 
• 137731-79-4 2,6-bis(4'-phenyl-2'-quinolinyl)pyridine 
• 143329-89-9 α,α'-dihydroxy-1,3-diethylpyridine 

Related news

Synthesis, anticancer activity and mechanism of iron chelator derived from 2,6-Diacetylpyridine (cas 1129-30-2) bis(acylhydrazones)07/11/2019

We synthesized five iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones) and proved their iron complexes structure by X–ray single crystal diffraction. These ligands have a significant anticancer proliferative activity and low cytotoxicity against normal cells. The Fe(III) comple...detailed

Relevant articles and documents

Controlled synthesis of 2-acetyl-6-carbethoxypyridine and 2,6-diacetylpyridine from 2,6-dimethylpyridine

The controlled syntheses of mono- and bis-acetylpyridine from the same starting material (2,6-dimethylpyridine) are reported, including the asymmetrical compound 2-acetyl-6-carbethoxypyridine, which has not before been reported. The influences of the amount of catalyst EtONa and the reaction conditions to the final products are also explored. A modification of the reported preparation for the 2,6-dipicolinic acid, 2,6-dicarbethoxypyridine and 2,6-diacetylpyridine with higher purity and improved yields is provided here, and the physical and spectral properties of these products are identical to those reported in the literature. Copyright Taylor & Francis, Inc.

A Straightforward Deracemization of sec-Alcohols Combining Organocatalytic Oxidation and Biocatalytic Reduction

An efficient organocatalytic oxidation of racemic secondary alcohols, mediated by sodium hypochlorite (NaOCl) and 2-azaadamantane N-oxyl (AZADO), has been conveniently coupled with a highly stereoselective bioreduction of the intermediate ketone, catalyzed by ketoreductases, in aqueous medium. The potential of this one-pot two-step deracemization process has been proven by a large set of structurally different secondary alcohols. Reactions were carried out up to 100 mm final concentration enabling the preparation of enantiopure alcohols with very high isolated yields (up to 98 %). When the protocol was applied to the stereoisomeric rac/meso mixture of diols, these were obtained with very high enantiomeric excesses and diastereomeric ratios (95 % yield, >99 % ee, >99: 1 dr).

Organopromoted Selectivity-Switchable Synthesis of Polyketones

In this work, an organopromoted metal-free pharmaceutical-oriented selectivity-switchable benzylic oxidation was developed, affording mono-, di-, and trioxygenation products, respectively, using oxygen as the oxidant under mild conditions. This process facilitates dioxygenation of 2,6-benzylic positions of heterocycles, which could be inhibited by heterocycle chelation to the metal cocatalysts. Enantiopure chiral ketones could also be prepared. The noninvolvement of transition metals and toxins avoids metal or hazardous residues, consequently ensuring a final-stage gram-scale synthesis of Lenperone.