1433459-97-2Relevant academic research and scientific papers
Convergent strategy towards the synthesis of restricted analogues of peloruside A
Zimmermann, Nicolas,Pinard, Pierre,Carboni, Bertrand,Gosselin, Pascal,Gaulon-Nourry, Catherine,Dujardin, Gilles,Collet, Sylvain,Lebreton, Jacques,Mathe-Allainmat, Monique
, p. 2303 - 2315 (2013/05/09)
A rapid convergent strategy to access unsaturated analogues of peloruside A has been demonstrated. This is depicted as an original C11-C12 aldol connection between a C12-C20 ketone fragment and a C2-C11 pyran fragment bearing an aldehyde function, with high yield and a good level of diastereoselectivity. The desired unsaturated macrocycle was obtained by a late-stage ring closing metathesis reaction.
