143360-90-1

Basic information

• Product Name: Acetamide, N-[2-(1-cycloocten-1-ylethynyl)phenyl]-2,2,2-trifluoro-
• CAS NO: 143360-90-1
• Molecular Formula: C18H18F3NO
• Molecular Weight: 321.342
• Mol File: 143360-90-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[2-(1-cycloocten-1-ylethynyl)phenyl]-2,2,2-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-(1-cycloocten-1-ylethynyl)phenyl]-2,2,2-trifluoro-(143360-90-1)
• EPA Substance Registry System: Acetamide, N-[2-(1-cycloocten-1-ylethynyl)phenyl]-2,2,2-trifluoro-(143360-90-1)

Safety Data

• Hazardous Substances Data: 143360-90-1(Hazardous Substances Data)

Upstream product

• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 52670-38-9 2-ethynylaniline 
• 28075-35-6 1-cyclooctenyl triflate 
• 143360-93-4 N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1356491-15-0 4-(2-cyclooct-1-en-1-yl-1H-indol-3-yl)-6,8-difluoro-2-(2-methoxyphenyl)quinoline 

Relevant articles and documents

2-Substituted-3-acylindoles through the palladium-catalysed carbonylative cyclization of 2-alkynyltrifluoroacetanilides with aryl halides and vinyl triflates

The palladium-catalysed reaction of readily accessible 2- alkynyltrifluoroacetanilides with aryl halides and vinyl triflates under a carbon monoxide atmosphere (1 or 7 atm) and in the presence of potassium carbonate produces 2-substituted-3-acyl indoles in fair to good yield. The acidity of the nitrogen-hydrogen bond proved to be of primary importance for the success of the reaction. The methodology has been applied to the synthesis of pravadoline, a drug that shows analgesic activity against postoperative pain in man.