28075-35-6

Usage

Uses

Used in Organic Synthesis:
(1E)-cyclooct-1-en-1-yl trifluoromethanesulfonate is used as a reagent for various chemical reactions, such as nucleophilic substitution and elimination reactions, due to its high reactivity and the presence of the trifluoromethanesulfonate group.
Used in Pharmaceutical Synthesis:
(1E)-cyclooct-1-en-1-yl trifluoromethanesulfonate is used as a reagent in the synthesis of complex organic molecules and pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Carbon-Carbon Bond Formation:
(1E)-cyclooct-1-en-1-yl trifluoromethanesulfonate is used as a valuable tool in the field of organic chemistry for forming stable carbon-carbon bonds, which is essential for creating new organic compounds and advancing chemical research.

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 502-49-8 cycloactanone 
• 456-64-4 phenyl trifluoromethanesulfonamide 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 502-42-1 cycloheptanone 

Downstream Products

• 124643-41-0 2-((E)-2-Cyclooct-1-enyl)ethynyl-phenylamine 
• 143360-90-1 2-(cyclooct-1-enyl)ethynyltrifluoroacetanilide 
• 143360-83-2 3-((E)-Cyclooct-1-enyl)-2-phenyl-1H-indole 
• 96308-48-4 cyclooctene-1-carbaldehyde 
• 130721-59-4 4-methylene-3-(toluene-4-sulfonyl)-1-oxa-3-azaspiro[4.5]decan-2-one 
• 448211-45-8 (Z)-2-(cyclooct-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 137407-47-7 (E)-1-phenylcyclooctene 
• 448211-45-8 2-(cyclooct-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 67788-08-3 (E)-cyclooct-1-en-1-yl(phenyl)methanone 

Relevant academic research and scientific papers

Generation of cycloalkynes through deprotonation of cyclic enol triflates with magnesium bisamides

Deprotonative generation of cyclohexynes, cycloheptynes, and cyclooctynes was achieved by controlling the reactivities of transient anionic species from the corresponding enol triflates with magnesium bis(2,2,6,6-tetramethylpiperidide) as a base. The star

Catalytic Multisite-Selective Acetoxylation Reactions at sp2 vs sp3 C-H Bonds in Cyclic Olefins

The first Pd-catalyzed multisite-selective acetoxylation reactions are disclosed at an unactivated alkene sp2 C-H bond versus secondary allylic sp3 C-H bond in cyclic olefins via the modulation of directing groups. The different directing groups overcome the key challenge in differentiating C-H bonds and provide a new controlling approach for site-specific C-H activation. A wide variety of substrates are readily acetoxylated under operationally simple conditions. Mechanistic studies suggest that different Pd (IV) intermediates were involved in the multisite-selective acetoxylation reactions.

Selective iron-catalyzed cross-coupling reactions of Grignard reagents with enol triflates, acid chlorides, and dichloroarenes

Cheap, readily available, air stable, nontoxic, and environmentally benign iron salts such as Fe(acac)3 are excellent precatalysts for the cross-coupling of Grignard reagents with alkenyl triflates and acid chlorides. Moreover, it is shown that dichloroarene and -heteroarene derivatives as the substrates can be selectively monoalkylated by this method. All cross-coupling reactions proceed very rapidly under notably mild conditions and turned out to be compatible with a variety of functional groups in both reaction partners. A detailed analysis of the preparative results suggests that iron-catalyzed C-C bond formations can occur via different pathways. Thus, it is likely that reactions of methylmagnesium halides involve iron-ate complexes as the active components, whereas reactions of Grignard reagents with two or more carbon atoms are effected by highly reduced iron-clusters of the formal composition [Fe(MgX)2]n generated in situ. Control experiments using the ate-complex [Me4Fe]Li2 corroborate this interpretation.

New electrochemical carboxylation of vinyl triflates. Synthesis of β-keto carboxylic acids

Electrochemical reduction of alicyclic vinyl triflates (1a-1e) in a DMF solution containing 0.1 M Bu4NBF4 under an atmospheric pressure of carbon dioxide with a platinum cathode and a magnesium anode resulted in the cleavage of an ox

The Conversion of Vinyl Triflates into γ'-Hydroxy-α,β-enones

Vinyl triflates have been converted into γ'-hydroxy-α,β-enones through their palladium-catalysed coupling with 1-butyn-4-ols followed by the reaction of the obtained 1-hydroxy-3-yn-5-enes in an acidic CH2Cl2/3N HCl two-phase system in the presence of n-Bu

A METHOD FOR THE REGIOSPECIFIC SYNTHESIS OF ENOL TRIFLATES BY ENOLATE TRAPPING

Enol triflates can be prepared in high yield from regiospecifically generated enolates by trapping with N-phenyltrifluoromethanesulfonimide.