1433722-35-0

Upstream product

• 1433722-27-0 (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide 
• 1433722-21-4 (R)-5-((dibenzylamino)methyl)dihydrofuran-2(3H)-one 
• 1433722-31-6 (R)-8-(dibenzylamino)-7-hydroxyoctan-4-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 565176-84-3 (S)-N,N-dibenzylamino-1-(oxiran-2-ylmethyl)methylamine 
• 103-49-1 dibenzylamine 

Relevant academic research and scientific papers

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, (3R,6S)-epi-pseudoconhydrine and (3R,6R)-pseudoconhydrine in memory of Dr. K. Anji Reddy, the founder of Dr. Reddy's Laboratories Ltd.

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, epi-pseudoconhydrine (1) and pseudoconhydrine (2) has been developed starting from enantiopure (S)-epichlorohydrin. The key steps in the synthesis of these alkaloids involved α-aminobutyrolactone ring opening with N,O-dimethyhydroxyl amine followed by a Grignard reaction and cascade debenzylation-reductive aminative cyclization under hydrogenation conditions. High de was obtained in the synthesis of epi-pseudoconhydrine (1).