143378-40-9

Upstream product

• 143377-85-9 2-(tert-Butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-phenyl)-1-phenyl-ethylamine; hydrochloride 
• 143378-38-5 N-<2-(3,4-dimethoxyphenyl)-1-phenyl-2-(tert-butyldiphenylsilyloxy)ethyl>formamide 

Downstream Products

• 143378-43-2 (3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)tetrahydroisoquinoline 
• 143378-42-1 (3R*,4S*)-3-phenyl-4-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Silicon-mediated isoquinoline synthesis: Preparation and stereochemical characterization of 4-hydroxy-3-phenylisoquinolines

The silicon-mediated synthesis of 4-hydroxy-6,7-dimethoxy-3-phenylisoquinoline derivatives is reported. The described procedure implies synthetically useful yields and a high degree of stereoselectivity.