1433997-01-3

Basic information

• Product Name: Mal-PEG2-NHS ester
• Synonyms: Mal-PEG2-NHS ester;2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)propanoate
• CAS NO: 1433997-01-3
• Molecular Formula: C15H18N2O8
• Molecular Weight: 354.31202
• Mol File: 1433997-01-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 524.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Solubility: Soluble in DCM
• PKA: -2.34±0.20(Predicted)
• CAS DataBase Reference: Mal-PEG2-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG2-NHS ester(1433997-01-3)
• EPA Substance Registry System: Mal-PEG2-NHS ester(1433997-01-3)

Safety Data

• Hazardous Substances Data: 1433997-01-3(Hazardous Substances Data)

Usage

Description

Mal-PEG2-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. It is designed to enhance the solubility of biomolecules in aqueous media and facilitate their covalent attachment to other molecules through specific chemical reactions. The hydrophilic PEG spacer increases solubility, while the NHS ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group reacts with a thiol group to form a covalent bond, enabling the connection of a biomolecule with a thiol.

Uses

Used in Pharmaceutical Industry:
Mal-PEG2-NHS ester is used as a reagent for the preparation of antibody-drug conjugates (ADCs) for targeting human-antigen in the fight against various types of cancers. The unique structure of Mal-PEG2-NHS ester allows for the formation of stable covalent bonds with biomolecules, such as antibodies, and the subsequent attachment of therapeutic drugs. This process enhances the specificity and efficacy of the treatment, as the drug is selectively delivered to cancer cells, minimizing damage to healthy cells.
Used in Drug Delivery Systems:
In the field of drug delivery, Mal-PEG2-NHS ester is employed as a versatile tool for the development of novel drug conjugates and targeted therapies. Its ability to form stable covalent bonds with a wide range of biomolecules makes it an attractive option for the creation of targeted drug delivery systems. These systems can improve the bioavailability, solubility, and overall therapeutic efficacy of various drugs, particularly in the treatment of cancer.
Used in Bioconjugation:
Mal-PEG2-NHS ester is also used as a bioconjugation agent, enabling the covalent attachment of various functional groups, such as fluorescent tags, enzymes, or other proteins, to biomolecules of interest. This allows for the development of new diagnostic tools, sensors, and research reagents, as well as the enhancement of existing ones, by improving their stability, solubility, and functionality.