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14340-04-6

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14340-04-6 Usage

General Description

17α-Acetoxy-19-norpregna-4,9-diene-3,20-dione, also known as norethindrone acetate, is a synthetic progestin and a derivative of the naturally occurring hormone progesterone. It is commonly used in hormonal contraceptive medications, such as birth control pills and hormone replacement therapy. Norethindrone acetate works by interfering with the normal menstrual cycle and preventing ovulation. Additionally, it can also alter the cervical mucus and the uterine lining, making it difficult for sperm to reach the egg and for a fertilized egg to implant itself in the uterus. This chemical compound has also been used in the treatment of irregular menstrual cycles, endometriosis, and as a component in menopausal hormone therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 14340-04-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,4 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 14340-04:
(7*1)+(6*4)+(5*3)+(4*4)+(3*0)+(2*0)+(1*4)=66
66 % 10 = 6
So 14340-04-6 is a valid CAS Registry Number.

14340-04-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 17α-Acetoxy-19-norpregna-4,9-diene-3,20-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14340-04-6 SDS

14340-04-6Synthetic route

acetic acid
64-19-7

acetic acid

3,3-[1,2-ethanediylbis(oxy)]-17α-hydroxy-19-norpregna-5(10),9(11)-diene-20-one
42982-49-0

3,3-[1,2-ethanediylbis(oxy)]-17α-hydroxy-19-norpregna-5(10),9(11)-diene-20-one

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; trifluoroacetic anhydride In dichloromethane at 0℃; for 0.166667h;99%
With toluene-4-sulfonic acid; trifluoroacetic anhydride In dichloromethane at 0℃; for 0.166667h;99%
acetic acid
64-19-7

acetic acid

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione
14340-01-3

17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; trifluoroacetic anhydride In dichloromethane at 0℃; for 0.25h;62.3%
3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

3,3-(ethylene-dioxy)-17β-cyano-17α-hydroxy-19-norpregna-5(10),9(11)-diene

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PYRIMIDINE / toluene / 20 - 60 °C
2: tetrahydrofuran / toluene / 16 h / Inert atmosphere; Reflux
3: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C
View Scheme
ethylene deltenone
5571-36-8

ethylene deltenone

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid / methanol / 6 h / 20 °C
2: PYRIMIDINE / toluene / 20 - 60 °C
3: tetrahydrofuran / toluene / 16 h / Inert atmosphere; Reflux
4: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C
View Scheme
17β-cyano-3,3-[1,2-ethanediylbis(oxy)]-17α-trimethylsilyloxyestra-5(10),9(11)-diene
54690-63-0

17β-cyano-3,3-[1,2-ethanediylbis(oxy)]-17α-trimethylsilyloxyestra-5(10),9(11)-diene

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / toluene / 16 h / Inert atmosphere; Reflux
2: toluene-4-sulfonic acid; trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C
View Scheme
ethylene glycol
107-21-1

ethylene glycol

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

17α-acetoxy-3,3[1,2-ethanediylbis(oxy)]-19-norpregna-5(10),9(11)-diene-20-one
240806-31-9

17α-acetoxy-3,3[1,2-ethanediylbis(oxy)]-19-norpregna-5(10),9(11)-diene-20-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester In dichloromethane at 20℃; for 0.5h;100%
In toluene Reflux;54 g
17α-acetoxy-19-norpregna-4,9-diene-3,20-dione
14340-04-6

17α-acetoxy-19-norpregna-4,9-diene-3,20-dione

17α-acetoxy-3,3[1,2-ethanediylbis(oxy)]-19-norpregna-5(10),9(11)-diene-20-one
240806-31-9

17α-acetoxy-3,3[1,2-ethanediylbis(oxy)]-19-norpregna-5(10),9(11)-diene-20-one

Conditions
ConditionsYield
Stage #1: ethylene glycol; toluene-4-sulfonic acid In toluene Heating / reflux;
Stage #2: 17α-acetoxy-19-norpregna-4,9-diene-3,20-dione In toluene Heating / reflux;

14340-04-6Downstream Products

14340-04-6Relevant articles and documents

20-ketofatty -11β-arylpropionic agonists or antagonists and having its deriv. nonsteroid antiandrogenic characteristics

-

, (2019/05/08)

The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.

17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties

-

Page/Page column 20, (2008/06/13)

The invention is directed to a novel class of 17β-acyl-17α-propynyl steroids which exhibit potent antiprogestational activity.

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