1434003-99-2

Upstream product

• 1260650-82-5 C₁₁H₁₁NO₂ 
• 1383604-52-1 methyl 2-(4-methoxybenzyl)hydrazinecarboxylate 
• 1434003-91-4 ethyl 3-azido-4-ethynylbenzoate 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 1434004-10-0 6-ethyl 1-methyl 3-benzyl-2-(4-methoxybenzyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate 

Relevant academic research and scientific papers

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: Application to the development of a new class of CK2 inhibitors

Pyrazolo[4,3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4,3-b]indoles and related dihydropyrazolo[4,3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4,3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors.