143407-59-4Relevant articles and documents
A new and expeditious strategy for the synthesis of β-amino acids from Δ2-oxazolines
Fustero, Santos,Díaz, Ma Dolores,Navarro, Antonio,Salavert, Esther,Aguilar, Enrique
, p. 703 - 712 (2007/10/03)
A new, mild two-step synthesis of racemic β-amino acids starting from 2-alkyl-Δ2-oxazolines is described. The process implies the initial formation of masked N-substituted or N-unsubstituted β-enamino acid derivatives followed by chemoselective reduction of the enamino moiety. The process takes place with high yields, total chemoselectivity and moderate diastereoselectivity.
Synthesis and reactivity of β-amino-α,β-unsaturated oxa- and thiazolines
Fustero,Diaz,Barluenga,Aguilar
, p. 3801 - 3804 (2007/10/02)
A simple and efficient route to masked β-amino-α,β-unsaturated acids 3 by reaction of metalated oxa- and thiazolines with nitriles has been developed. The reactivity of 3 has also been explored.
