221907-00-2

Basic information

• Product Name: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine
• Synonyms: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine
• CAS NO: 221907-00-2
• Molecular Weight: 202.256
• Mol File: 221907-00-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine(221907-00-2)
• EPA Substance Registry System: (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine(221907-00-2)

Safety Data

• Hazardous Substances Data: 221907-00-2(Hazardous Substances Data)

Upstream product

• 1120-64-5 2-methyl-4,5-dihydro-1,3-oxazole 
• 104-85-8 para-methylbenzonitrile 

Downstream Products

• 143407-59-4 2-(2-amino-2-p-tolyl)ethyl-2-oxazoline 
• 583030-67-5 3-(2-chloroethyl)-6-(4-methylphenyl)-1,2,3,4-tetrahydro-2,4-pyrimidindione 
• 1144524-90-2 3-(2-fluoroethyl)-6-(4-methylphenyl)-1,2,3,4-tetrahydro-2,4-pyrimidindione 
• 1144524-88-8 3-(2-hydroxyethyl)-6-(4-methylphenyl)-1,2,3,4-tetrahydro-2,4-pyrimidindione 
• 68208-18-4 3-amino-3-(p-tolyl)propionic acid 
• 583030-52-8 7-(4-methylphenyl)-2,3-dihydro-5H-[1,3]oxazolo[3,2-c]pyrimidin-5-one 
• 583030-51-7 7-(4-methylphenyl)-2,3-dihydro-5H-[1,3]oxazolo[3,2-a]pyrimidin-5-one 
• 221907-27-3 (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1-propen-1-amine 
• 221907-44-4 (Z)-2-(4,5-dihydro-1,3-oxazol-2-yl)-1-(4-methylphenyl)-1,4-pentadien-1-amine 

Relevant articles and documents

A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives

A new method of synthesis of racemic β-amino acids 6 by reduction of masked N-substituted and N-unsubstituted β-enamino acid derivatives 4 via C- protected β-amino acids 5 is described. The process occurs with high yields, total chemoselectivity and moderate diastereoselectivity. Readily available starting materials, inexpensive reagents and mild conditions are used to furnish derivatives 5 and 6.

Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected β-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a 'one-pot' preparation of 2 from 3 are also described.