1434081-75-0

Basic information

• Product Name: C₄₂H₄₅N₅O₉S
• CAS NO: 1434081-75-0
• Molecular Weight: 795.913
• Mol File: 1434081-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₂H₄₅N₅O₉S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₂H₄₅N₅O₉S(1434081-75-0)
• EPA Substance Registry System: C₄₂H₄₅N₅O₉S(1434081-75-0)

Safety Data

• Hazardous Substances Data: 1434081-75-0(Hazardous Substances Data)

Upstream product

• 63758-12-3 6-chlorosulfonyl-1,4-benzodioxane 
• 23687-27-6 8-aminoisoquinoline 
• 1434081-77-2 C₃₃H₃₇N₃O₉S 
• 1434081-79-4 N-(((2R,3R)-10-amino-5-((S)-1-((4-methoxybenzyl)oxy)-propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b]-[1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b]-[1,4]dioxine-6-sulfonamide 
• 1434081-78-3 N-(((2R,3R)-5-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-10-nitro-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]-oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]-dioxine-6-sulfonamide 
• 1434081-81-8 C₂₄H₃₁N₃O₆ 
• 1434081-80-7 C₃₁H₄₅N₃O₈Si 

Relevant articles and documents

Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility

We previously reported the discovery of BRD0476 (1), a small molecule generated by diversity-oriented synthesis that suppresses cytokine-induced β-cell apoptosis. Herein, we report the synthesis and biological evaluation of 1 and analogues with improved aqueous solubility. By replacing naphthyl with quinoline moieties, we prepared active analogues with up to a 1400-fold increase in solubility from 1. In addition, we demonstrated that 1 and analogues inhibit STAT1 signal transduction induced by IFN-γ.