14341-86-7

Usage

Uses

Used in Pharmaceutical Industry:
SUCCINIC-D4 ANHYDRIDE is used as a synthetic intermediate for the production of propanoyloxy derivatives, which function as drug absorption modifiers. These derivatives enhance the bioavailability and absorption of certain drugs, thereby improving their overall effectiveness.
Used in Research and Development:
SUCCINIC-D4 ANHYDRIDE serves as a reagent for the development of novel non-carboxylate inhibitors of AKR1C3, an enzyme involved in various biological processes. By inhibiting this enzyme, researchers can study its role in different pathways and potentially develop new therapeutic strategies for related conditions.

InChI:InChI=1/C4H4O3/c5-3-1-2-4(6)7-3/h1-2H2/i1D2,2D2

Upstream product

• 77969-58-5 1,3-bis(dideuteriomethylene)cyclopentane 
• 14493-42-6 2,2,3,3-tetradeuterio-succinic acid 

Downstream Products

• 929917-78-2 4-{(S)-2-[4-(4-chloro-phenyloxy)-phenoxymethyl]-pyrrolidin-1-yl}-4-oxo-butyric acid (d4) 
• 505077-12-3 C₃₉H₄₇⁽²⁾H₄N₇O₁₁S 

Relevant academic research and scientific papers

BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

Degenerate Thermal Rearrangement of 1,3-Dimethylenecyclopentane. Evidence for Partially Stereospecific Biradical Formation and Closure in 1,3 Shift

Parolysis of 1,3-bis(dideuteriomethylene)cyclopentane at 370 deg C resulted in a first-order degenerate rearrangement in which the 1,3- and 3,3-shift products were formed in a 2:1 ratio, respectively, indicating the intermediacy of an effectively orthogonal 2,2'-bis(allylmethane) biradical.Pyrolysis of trans- and cis-4,5-dimethyl-1,3-dimethylenecyclopentane (T and C) gave 1,3- and 3,3-shift products with stereochemistry consistent with predominant conrotatory-bevel ring opening to produce the orthogonal diradical directly.Pyrolysis of optically active T gave the 1,3-shift products with 20.8percent inversion of configuration of the migrating carbon indicative of partial stereospecific closure of the biradical.Comparative pyrolysis of optically active T and its bis(dideuteriomethylene) derivative revealed no secondary kinetic deuterium isotop effect, but an alternation in the extent of racemization of starting material and amounts of 1,3- and 3,3-shift products indicates a product-determining isotope effect.These data provide further evidence for an intermediate.