143416-56-2

Upstream product

• 821-09-0 n-Pent-4-enyl alcohol 
• 64694-23-1 2,3,4-tri-O-benzyl-α-L-fucopyranosyl chloride 
• 73-34-7 6-deoxy-L-galactose 
• 67576-77-6 1-O-methyl 2,3,4-tri-O-benzyl-L-fucopyranoside 
• 100-39-0 benzyl bromide 
• 676518-71-1 1-O-(4-pentenyl)-L-fucopyranoside 

Downstream Products

• 143416-66-4 benzyl O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-O-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->2)>-O-(4,6-di-O-benzyl-β-D-galactopyranosyl)-(1->3)-2-acetamido-4,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 143416-66-4 benzyl O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->3)-O-<(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->2)>-O-(4,6-di-O-benzyl-β-D-galactopyranosyl)-(1->3)-2-acetamido-4,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 

Relevant academic research and scientific papers

Design and Synthesis of Peptide Mimetics of GDP-Fucose: Targeting Inhibitors of Fucosyltransferases

Novel peptide mimetics of GDP-fucose were designed and synthesized targeting inhibitors of the fucosyltransferases that transfer L-fucose from GDP-fucose to oligosaccharides, on the basis of the background that nikkomycin Z, a peptide mimetic of UDP-N-acetylglucosamine, shows potent inhibitory activity toward an N-acetylglucosamine transfer enzyme. The synthetic routes of the GDP-fucose mimetics take advantage of an enzymatic aldol reaction catalyzed by L-threonine aldolase to prepare the guanine carrying β-hydroxy-α- L-amino acid, a key synthetic intermediate.

n-Pentenyl glycosides in the efficient assembly of the blood group substance B tetrasaccharide

The fact that n-pentenyl glycosides (nPGs) are stable to a wide variety of reaction conditions but yet can be chemospecifically activated is advantageous for the efficient, convergent assembly of oligosaccharides. The nPGs are prepared directly from the a