1434160-07-2Relevant academic research and scientific papers
Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles
Arigela, Rajesh K.,Sharma, Sudhir K.,Kumar, Brijesh,Kundu, Bijoy
supporting information, p. 401 - 405 (2013/03/28)
A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide-internal alkyne 1,3-dipolar cycloaddition domino sequence has been described. The efficacy of the methodology has been demonstrated by treating various 2-alkynylindoles (aromatic/aliphatic) with epichlorohydrin and sodium azide furnishing annulated tetracyclic indolodiazepinotriazoles in satisfactory yields.
