143418-80-8

Upstream product

• 18457-04-0 bis(trimethylsilyl) malonate 
• 5065-11-2 3-benzyloxy-4,5-dimethoxybenzoyl chloride 
• 5651-55-8 3-(benzyloxy)-4,5-dimethoxybenzoic acid 

Downstream Products

• 1027080-33-6 [1-(3-Benzyloxy-4,5-dimethoxy-phenyl)-vinyloxy]-trimethyl-silane 
• 180900-57-6 1,4-Bis-(3-benzyloxy-4,5-dimethoxy-phenyl)-butane-1,4-dione 
• 143418-81-9 6-(3-benzyloxy-4,5-dimethoxy)phenyl-1,3-dioxolo[4,5-g]quinoline 

Relevant academic research and scientific papers

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.