143420-53-5

Basic information

• Product Name: 2-Hexenamide, 2-cyano-5-methyl-
• Synonyms: 2-Hexenamide, 2-cyano-5-methyl-
• CAS NO: 143420-53-5
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19
• Mol File: 143420-53-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Hexenamide, 2-cyano-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexenamide, 2-cyano-5-methyl-(143420-53-5)
• EPA Substance Registry System: 2-Hexenamide, 2-cyano-5-methyl-(143420-53-5)

Safety Data

• Hazardous Substances Data: 143420-53-5(Hazardous Substances Data)

Upstream product

• 185815-56-9 2,4-dicyano-3-isobutylglutaramide 

Relevant articles and documents

Pharmaceutical intermediate impurity, preparation method and applications thereof

The invention provides a pregabalin intermediate impurity, a preparation method and applications thereof, wherein the impurity is important for the quality control of a pregabalin intermediate. The invention further discloses a preparation method of the pregabalin intermediate impurity, wherein the method comprises: adding 2,4-dicyano-3-isobutylglutaramide to purified water, carrying out stirringheating to a temperature of 30-80 DEG C, and carrying out a reaction; when the solid is precipitated during the reaction, cooling the reaction system to a temperature of 0-20 DEG C, and crystallizingfor more than 0.5 h; and filtering while cold, washing the filter cake once with purified water, and drying to obtain the pregabalin intermediate impurity (E)-2-cyano-5-methyl-2-enamide. According tothe present invention, the preparation method has advantages of safe and environmentally-friendly reagent, mild reaction condition, simple treatment, short reaction period, high product yield and goodproduce quality.