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Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dicyano-3-(2-Methylpropyl)-pentanediaMide is used as an impurity in the production of Pregabalin, which is a GABA analogue. Pregabalin is utilized as an anticonvulsant for the treatment of various conditions such as epilepsy, neuropathic pain, and generalized anxiety disorder. The presence of this impurity in Pregabalin may affect the drug's efficacy and safety, making it crucial to monitor and control its levels during the manufacturing process.
As an impurity in Pregabalin, 2,4-Dicyano-3-(2-Methylpropyl)-pentanediaMide may also be indirectly involved in other applications where Pregabalin is used, such as in the treatment of fibromyalgia, diabetic neuropathy, and other related conditions. However, its specific role and impact in these applications would depend on the concentration and interaction of the impurity with the active pharmaceutical ingredient, Pregabalin.

Upstream product

• 590-86-3 isovaleraldehyde 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 143420-53-5 (E)-2-cyano-5-methylhex-2-enamide 
• 181289-25-8 (3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid 

Relevant academic research and scientific papers

Preparation method and application of high-purity dimethyl 3-isobutylglutarate

The invention provides a preparation method and application of high-purity dimethyl 3-isobutylglutarate. Specifically, the invention provides the method for preparing dimethyl 3-isobutylglutarate shown as a formula 2, and the method comprises the step of enabling 3-isobutylglutaric acid to react in methanol in the presence of potassium permanganate and concentrated sulfuric acid, so as to obtain the high-purity dimethyl 3-isobutylglutarate. The method is simple, easy to control, high in product conversion rate, mild in reaction condition, convenient for industrial production and low in cost, the product is easy to purify, and the purity is up to 99% or above.

Preparation method for 3-carbamoymethyl-5-methylhexanoic acid

The invention relates to a preparation method for 3-carbamoymethyl-5-methylhexanoic acid, and the product can be used as a pregabalin intermediate. The preparation method comprises the steps that a condensation compound is generated by catalytic condensation using isovaleraldehyde and cyanoacetamide as raw materials under mild conditions; the condensation compound is hydrolyzed to generate 3-Isobutylglutaric acid under acidic conditions; 3-isobutylglutaric anhydride is generated through an anhydride reaction; the final product 3-carbamoymethyl-5-methylhexanoic acid is generated through an amidation reaction. The preparation method for 3-carbamoymethyl-5-methylhexanoic acid effectively improves the condensation reaction efficiency through catalytic condensation of a base catalyst, and is high in production yield, less in by-products, mild in reaction conditions, and is beneficial to treatment of three wastes, and provides an environment-friendly technological route for industrialized mass production. The preparation method is an operation-safety, high-yield, low-cost and environment-friendly route.