143426-52-2

Basic information

• Product Name: 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE
• Synonyms: 1-[4-(chloromethyl)phenyl]-1H-pyrazole(SALTDATA: FREE);1-[4-(ChloroMethyl)phenyl]pyrazole;1H-Pyrazole,1-[4-(chloroMethyl)phenyl]-
• CAS NO: 143426-52-2
• Molecular Formula: C₁₀H₉ClN₂
• Molecular Weight: 192.65
• Mol File: 143426-52-2.mol

Chemical Properties

• Boiling Point: 303.9°Cat760mmHg
• Flash Point: 137.6°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.00163mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.05±0.10(Predicted)
• CAS DataBase Reference: 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE(143426-52-2)
• EPA Substance Registry System: 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE(143426-52-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 143426-52-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE is used as a building block for synthesizing other organic compounds with specific properties, potentially contributing to the development of new pharmaceutical agents. Its unique structure may enable the creation of molecules with targeted therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE may serve as a precursor for the synthesis of compounds with pesticidal or herbicidal properties, providing innovative solutions for crop protection and management.
Further research and development of 1-[4-(CHLOROMETHYL)PHENYL]-1H-PYRAZOLE HYDROCHLORIDE could reveal additional potential uses and benefits across different industries, expanding its applications and impact.

InChI:InChI=1/C10H9ClN2/c11-8-9-2-4-10(5-3-9)13-7-1-6-12-13/h1-7H,8H2

Upstream product

• 400750-29-0 methyl 4-(1H-pyrazol-1-yI)benzenecarboxylate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 143426-47-5 4-pyrazol-1-yl-benzoic acid ethyl ester 
• 143426-49-7 1-(4-hydroxymethylphenyl)-1H-pyrazole 

Downstream Products

• 143426-55-5 2-(4-(1H-pyrazol-1-yl)phenyl)acetonitrile 
• 65476-24-6 [4-(1H-pyrazol-1-yl)phenyl]acetic acid 
• 139311-78-7 (4-Pyrazol-1-yl-phenyl)-acetic acid hydrazide 
• 66956-13-6 4-(pyrazol-1-yl)phenylacetic acid ethyl ester 

Relevant articles and documents

PYRROLIDINE GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, W, R3b, Z and p have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. (I) wherein each symbol is as described in the specification, or a salt thereof.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.