143427-56-9

Upstream product

• 18719-27-2 5-bromo-pent-2-yne 
• 100-46-9 benzylamine 
• 106060-18-8 methanesulfonic acid pent-3-ynyl ester 
• 72486-09-0 methanesulfonic acid but-3-ynyl ester 
• 3329-88-2 pent-3-yn-1-yl 4-methylbenzenesulfonate 
• 10229-10-4 pent-3-yn-1-ol 

Downstream Products

• 143427-59-2 1-Benzyl-4-iodo-3-methyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ethyl ester 
• 157948-79-3 N-Benzyl-N-(2-methylallyl)-N-(pent-3-ynyl)amine 
• 157948-98-6 N-Allyl-N-benzyl-N-(pent-3-ynyl)amine 
• 845252-91-7 N-benzyl-N-(pent-3-ynyl)-1-cyclobutene-1-carboxamide 
• 1039627-08-1 C₁₂H₁₇N 
• 1258537-90-4 diethyl 2-(benzyl(pent-3-yn-1-yl)amino)malonate 
• 1349835-63-7 (C₆H₅C₆H₄((CH₃)3C)2P)AuCCC₄H₉ 

Relevant academic research and scientific papers

TETRAHYDROISOQUINOLINE DERIVATIVES

Compounds of Formula (I) are disclosed and methods of treating viral infections with compositions comprising such compounds.

Iodocarbamation of N-Homopropargyl Carbamates: Mild and Stereoselective Entry to Functionalized Oxazinan-2-ones

An efficient and general iodocarbamation of benzyl N-homopropargylcarbamates has been developed by using iodine as the electrophilic agent. This regio- and stereoselective cyclization yielded (E)-6-iodomethyleneoxazinan-2-ones, which can be further transformed through palladium cross-coupling reactions followed by hydrogenation to produce 1,3-oxazinan-2-ones.

Mechanistic study of gold(I)-catalyzed hydroamination of alkynes: Outer or inner sphere mechanism?

An experimental mechanistic study of the gold(I)-catalyzed hydroamination shows the formation of conformationally flexible auro-iminium salts Au-Im, which originate from the protonation of a vinyl gold species. Rotation around the C-CAu bond is the reason

Palladium-catalysed cyclisation of N-alkynyl aminomalonates

Go around in (hetero)cycles! The palladium-catalysed tandem cyclisation/coupling reaction of alkynyl- and alkenyl-substituted aminomalonates leads to highly functionalised pyrrolidines and piperidines in good yield (see scheme). The reaction allows efficient access to a broad range of synthetically valuable building blocks.

Zirconocene-mediated synthesis of 3,4-disubstituted piperidines and reduced isoquinolines

Intramolecular cocyclisation of 4-azaocta-1,7-dienes, -1-en-7-ynes, -7- en-1-ynes and -1,7-diynes using 'zirconocene' equivalents affords 3-aza-8- zirconabicyclo[4.3.0]nonanes, -6-enes, -9-enes or -6,9-dienes. Protonolysis, iodinolysis, or carbonylation of these complexes affords 3,4-disubstitued piperidines. Exocyclic 1,3-dienes formed from the coupling/protonolysis of 4- azaocta-1,7-diynes react with activated dienophiles to yield reduced isoquinolines.