72486-09-0Relevant articles and documents
Synthesis and evaluation of Re/99mTc(I) complexes bearing a somatostatin receptor-targeting antagonist and labeled via a novel [N,S,O] clickable bifunctional chelating agent
Radford, Lauren L.,Papagiannopoulou, Dionysia,Gallazzi, Fabio,Berendzen, Ashley,Watkinson, Lisa,Carmack, Terry,Lewis, Michael R.,Jurisson, Silvia S.,Hennkens, Heather M.
, p. 492 - 501 (2019)
The somatostatin receptor subtype 2 (SSTR2) is often highly expressed on neuroendocrine tumors (NETs), making it a popular in vivo target for diagnostic and therapeutic approaches aimed toward management of NETs. In this work, an antagonist peptide (ssts
Double Radical Cyclization/β-Fragmentation of Acyclic ω-Yne Vinyl Sulfides. Synthesis of 3-Vinyldihydrothiophene and Dihydrothiopyran Derivatives. A New Example of a 5-endo-trig Radical Cyclization
Journet, Michel,Rouillard, Alain,Cai, Dongwei,Larsen, Robert D.
, p. 8630 - 8631 (1997)
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A versatile new monomer family: Functionalized 4-vinyl-1,2,3-triazoles via click chemistry
Thibault, Raymond J.,Takizawa, Kenichi,Lowenheilm, Peter,Helms, Brett,Mynar, Justin L.,Frechet, Jean M. J.,Hawker, Craig J.
, p. 12084 - 12085 (2006)
Using facile, highly modular synthetic approaches, a new monomer family based on a 1,2,3-triazole-4-vinyl building block has been prepared, and various functional derivatives have been obtained. Subsequent homo- and copolymerization of these novel functionalized monomers gives polymeric materials with unique physical properties, combining many attractive features of more traditional monomers, such as styrene, vinylpyridine, and meth/acrylates. Copyright
Discovery of a novel family of FKBP12 “reshapers” and their use as calcium modulators in skeletal muscle under nitro-oxidative stress
Aizpurua, Jesus M.,Miranda, José I.,Irastorza, Aitziber,Torres, Endika,Eceiza, Maite,Sagartzazu-Aizpurua, Maialen,Ferrón, Pablo,Aldanondo, Garazi,Lasa-Fernández, Haizpea,Marco-Moreno, Pablo,Dadie, Naroa,López de Munain, Adolfo,Vallejo-Illarramendi, Ainara
, (2021/01/25)
The hypothesis of rescuing FKBP12/RyR1 interaction and intracellular calcium homeostasis through molecular “reshaping” of FKBP12 was investigated. To this end, novel 4-arylthioalkyl-1-carboxyalkyl-1,2,3-triazoles were designed and synthesized, and their e
Synthesis of Exo- and Endocyclic Enamides Through Copper-Catalyzed Regioselective Intramolecular N-Halovinylation
Bergeron, Jodrey,Daoust, Benoit,Gilbert, Nicolas,Lambolez, Pierre,Ricard, Simon
supporting information, (2020/05/04)
Cross-couplings between amides and 1,2-dihaloalkenes are an efficient and straightforward way to access β-haloenamides which, in turn, can be functionalized into complex, stereodefined enamide motifs. However, the intramolecular version of these cross-couplings, leading to cyclic β-haloenamides, has not been formally studied. In this paper, we report an investigation of factors affecting the efficiency of the reaction and its selectivity between potential exo and endo cyclization products. We demonstrate that exo/endo selectivity is largely determined by ring strain, whether it arises from the size of the resulting ring or from the structure of the starting compound, but that selectivity can also be modulated by varying reaction conditions. Finally, we show that resulting β-haloenamides readily undergo transition metal-catalyzed reactions, making this sequence a viable way to access highly functionalized cyclic enamides.
