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Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique chemical structure allows for the development of drugs that can modulate the activity of glutamate receptors, which are implicated in the pathophysiology of various mental illnesses such as schizophrenia.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid serves as a valuable building block for the synthesis of diverse organic compounds. Its properties make it suitable for the creation of new molecules with potential therapeutic applications, particularly in the treatment of neurological and psychiatric disorders.
Used in Agrochemical Development:
Beyond its applications in human health, 3-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid also finds use in the agrochemical industry. Its unique structure and properties can be leveraged to develop new compounds with pesticidal or herbicidal activity, contributing to more effective and targeted crop protection strategies.

InChI:InChI=1/C10H10F3NO2/c11-10(12,13)7-3-1-2-6(4-7)8(14)5-9(15)16/h1-4,8H,5,14H2,(H,15,16)

Upstream product

• 141-82-2 malonic acid 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 1228570-45-3 methyl 3-amino-3-(3-(trifluoromethyl)phenyl)propanoate 
• 501015-18-5 3-{[(tert-butoxy)carbonyl]amino}-3-[3-(trifluoromethyl)phenyl]propanoic acid 

Relevant academic research and scientific papers

Iridium-catalysed C-H borylation of β-aryl-aminopropionic acids

Iridium-catalysed catalytic, regioselective C-H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through sequential one-pot functionalisation reactions to give diverse building blocks for medicinal chemistry. The C-H borylation is also effective for dipeptide substrates. We have exemplified this methodology in the synthesis of a pan αv integrin antagonist.

SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS

The present invention relates to a compound of the general formula (I). The compounds of formula I are useful for treatment of a cardiac disease, disorder or condition in a mammal.

BENZIMIDAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS

The present invention relates to compounds of the general formula (I). The compounds of formula I are potassium channel inhibitors useful for treatment of a cardiac disease, disorder or condition in a mammal.

Microwave Assisted Synthesis of Trifluoro Substituted 2-Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One-pot Condensation

Microwave-assisted efficient one-pot syntheses of trifluoro substituted 2-aminobenzimidazole derivative were synthesized using iodoacetic acid mediated cyclodesulfurization of thioureas. This method eliminates need to handle preformed substituted thioureas, requires lesser reaction time and temperature, is facile, and also gives higher yields of the target molecules.

NOVEL POTASSIUM CHANNEL INHIBITORS

The present invention relates to a compound of the general formula (I). The compounds of formula (I) are useful for treatment of a cardiac disease, disorder or condition in a mammal.