14344-46-8 Usage
Uses
Used in Pharmaceutical Industry:
3-MERCAPTO-2-(METHYLAMINO)PROPANOIC ACID HYDROCHLORIDE is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 3-MERCAPTO-2-(METHYLAMINO)PROPANOIC ACID HYDROCHLORIDE serves as a valuable compound for studying the properties and reactivity of thiol and amino groups. It can be used to explore new reaction mechanisms and develop novel synthetic methods.
Used in Biochemical Applications:
Due to its thiol and amino functional groups, 3-MERCAPTO-2-(METHYLAMINO)PROPANOIC ACID HYDROCHLORIDE can be employed in biochemical applications, such as the development of new bioactive molecules, enzyme inhibitors, or ligands for biological receptors.
Used in the Synthesis of Pyochelin Analogs:
3-MERCAPTO-2-(METHYLAMINO)PROPANOIC ACID HYDROCHLORIDE is used as an intermediate in the preparation of analogs of pyochelin (P840365), a siderophore of Pseudomonas aeruginosa. These analogs can be utilized for studying the interactions between siderophores and their target bacteria, potentially leading to the development of new antimicrobial agents.
Check Digit Verification of cas no
The CAS Registry Mumber 14344-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,4 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 14344-46:
(7*1)+(6*4)+(5*3)+(4*4)+(3*4)+(2*4)+(1*6)=88
88 % 10 = 8
So 14344-46-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO2S.ClH/c1-5-3(2-8)4(6)7;/h3,5,8H,2H2,1H3,(H,6,7);1H/t3-;/m0./s1
14344-46-8Relevant academic research and scientific papers
Total solid-phase synthesis of the azathiocoraline class of symmetric bicyclic peptides
Bayo-Puxan, Nuria,Fernandez, Ariadna,Tulla-Puche, Judit,Riego, Estela,Cuevas, Carmen,Alvarez, Mercedes,Albericio, Fernando
, p. 9001 - 9009 (2007/10/03)
Thiocoraline is a potent antitumor agent isolated from the marine organism Micromonospora sp. This symmetric bicyclic depsipeptide binds the minor groove of DNA. Here we report two solid-phase strategies for the syntheses of azathiocoraline and its analogues. The thioester linkage was replaced by an amide bond to improve the compound's pharmacokinetic properties. The first strategy is based on a convergent (4+4) approach, whilst the second is a stepwise synthesis, cyclizations in both approaches occurring on the solid support. These two strategies were designed to overcome problems caused by the presence of consecutive noncommercial N-methyl amino acids, to avoid epimerization during cyclization and/or fragment condensation, and to form the disulfide bridge under solid-phase conditions. The heterocyclic moiety was added in the last step of the synthesis to assist the preparation of libraries of new compounds with potential therapeutic applications.
