143443-34-9Relevant academic research and scientific papers
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
Santos, Ana R. N.,Sheldrake, Helen M.,Ibrahim, Ali I. M.,Danta, Chhanda Charan,Bonanni, Davide,Daga, Martina,Oliaro-Bosso, Simonetta,Boschi, Donatella,Lolli, Marco L.,Pors, Klaus
supporting information, p. 1476 - 1480 (2019/08/20)
Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
