89825-31-0Relevant academic research and scientific papers
Processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and intemediates thereof
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, (2008/06/13)
The present invention relates to a novel enantiospecific processes for preparing (S)-4-amino-hepta-5,6-dienoic acid and pharmaceutically acceptable salts thereof, which is useful as an irreversible inhibitor of GABA-T, to novel intermediates thereof, and a process for preparing an intermediate thereof.
Process for the production of (S)-vinyl and allenyl gaba
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, (2008/06/13)
The present invention is directed to a new class of pyrrolidinone derivatives that are useful as chemical intermediates in the synthesis of S-allenyl and S-vinyl GABA, both of which are antiepileptic agents.
Synthesis of optically pure mechanism-based inhibitors of γ aminobutyric acid aminotransferase (GABA-T) via enzyme-catalyzed resolution
Margolin, Alexey L.
, p. 1239 - 1242 (2007/10/02)
The kinetic resolution of γ-ethynyl-,γ-allenyl- and γ-vinyl GABA was accomplished by penicillin acylase-catalyzed hydrolysis of their N-phenylacetyl derivatives. The procedure employs inexpensive commercially available immobilized enzyme.
GENERAL SYNTHETIC ACCESS TO α-ALLENYL AMINES AND α-ALLENYL-α-AMINOACIDS AS POTENTIAL ENZYME ACTIVATED IRREVERSIBLE INHIBITORS OF PLP DEPENDENT ENZYMES
Casara, Patrick,Jund, Karin,Bey, Philippe
, p. 1891 - 1894 (2007/10/02)
The entitled allene derivatives have been prepared from the parent α-ethynyl amines and α-amino acids.The corresponding derivative of GABA, putrescine and phenylalanine have been found to be irreversible and time dependent inhibitors of GABA-T, ODC and ba
4-Amino-hepta-5,6-dienoic acid
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, (2008/06/13)
(R,S)- and (S)-4-amino-hepta-5,6-dienoic acid are novel inhibitors of gamma-aminobutyric acid transaminase (GABA-T).
