1434622-86-2

Upstream product

• 24395-14-0 (S)-N-(p-tolylsulfonyl)-2-phenylaziridine 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 24395-14-0 N-(p-tolylsulfonyl)-2-phenylaziridine 

Downstream Products

• 1434621-80-3 6,7-dimethoxy-4-phenyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline 
• 1434622-93-1 N-(3,4-dimethoxybenzyl)-N-(2-hydroxy-2-phenylethyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

A novel lewis acid catalyzed [3 + 3]-annulation strategy for the syntheses of tetrahydro-β-carbolines and tetrahydroisoquinolines

A novel Lewis acid catalyzed [3 + 3]-annulation process for the efficient syntheses of both tetrahydro-β-carbolines and tetrahydroisoquinolines from readily available benzylic alcohols and aziridines was developed, which would be a highly valuable complement to the widely used Pictet-Spengler reaction. A probable mechanism was proposed based on the isolation and characterization of two key intermediates. This strategy enables facile access to important alkaloid frameworks not easily available with other known methods.