143482-58-0Relevant articles and documents
6-azido-2-fluoropurine, useful in the synthesis of nucleosides
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, (2008/06/13)
This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.