1434871-32-5

Basic information

• Product Name: ethyl 2-(2,2-diphenylacetoxy)-3-oxobutanoate
• Synonyms: ethyl 2-(2,2-diphenylacetoxy)-3-oxobutanoate
• CAS NO: 1434871-32-5
• Molecular Weight: 340.376
• Mol File: 1434871-32-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2,2-diphenylacetoxy)-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2,2-diphenylacetoxy)-3-oxobutanoate(1434871-32-5)
• EPA Substance Registry System: ethyl 2-(2,2-diphenylacetoxy)-3-oxobutanoate(1434871-32-5)

Safety Data

• Hazardous Substances Data: 1434871-32-5(Hazardous Substances Data)

Upstream product

• 117-34-0 2,2-diphenylacetic acid 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 1434871-40-5 2-benzhydryl-4-methyloxazole-5-carboxylic acid 
• 1434871-43-8 2-benzhydryl-4-methyl-1H-imidazole-5-carboxylic acid 
• 1434874-03-9 2-benzhydryl-1,5-dimethyl-1,3-imidazole-4-càrboxyl-arginine 
• 1434874-05-1 2-benzhydryl-1,4-dimethyl-1,3-imidazole-5-càrboxyl-arginine 
• 1434873-26-3 (2-benzhydryl-4-methyl-1H-imidazole-5-carbonyl)-L-arginine 
• 1434873-10-5 (2-benzhydryl-4-methyloxazole-5-carbonyl)-L-arginine 

Relevant articles and documents

Potent heterocyclic ligands for human complement C3a receptor

The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR antagonist (IC50 μM), was transformed here into potent agonists (EC50 nM) of human macrophages (Ca2+ release in HMDM) by incorporating aromatic heterocycles. Antagonists were also identified. A linear correlation between binding affinity for C3aR and calculated hydrogen-bond interaction energy of the heteroatom indicated that its hydrogen-bonding capacity influenced ligand affinity and function mediated by C3aR. Hydrogen-bond accepting heterocycles (e.g., imidazole) conferred the highest affinity and agonist potency (e.g., 21, EC50 24 nM, Ca2+, HMDM) with comparable efficacy and immunostimulatory activity as that of C3a in activating human macrophages (Ca2+, IL1β, TNFα, CCL3). These potent and selective modulators of C3aR, inactivated by a C3aR antagonist, are stable C3a surrogates for interrogating roles for C3aR in physiology and disease.