1434873-26-3 Usage
Description
(2-benzhydryl-4-methyl-1H-imidazole-5-carbonyl)-L-arginine is a chemical compound that combines L-arginine, an essential amino acid involved in protein synthesis and nitric oxide production for cardiovascular health, with an imidazole-5-carbonyl group, a functional group present in various bioactive compounds. This unique combination may endow the compound with distinctive properties, making it a promising candidate for pharmaceutical and biomedical applications.
Uses
Used in Pharmaceutical Development:
(2-benzhydryl-4-methyl-1H-imidazole-5-carbonyl)-L-arginine is used as a potential pharmaceutical agent for its unique combination of L-arginine and imidazole-5-carbonyl group, which may offer novel therapeutic benefits in medicine.
Used in Biomedical Research:
In the field of biomedical research, (2-benzhydryl-4-methyl-1H-imidazole-5-carbonyl)-L-arginine serves as a subject of study to explore its potential applications and effects, given the distinctive properties conferred by its chemical structure.
Further research is necessary to fully understand the potential uses and effects of (2-benzhydryl-4-methyl-1H-imidazole-5-carbonyl)-L-arginine, as its role in medicine and other applications is still being explored.
Check Digit Verification of cas no
The CAS Registry Mumber 1434873-26-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,4,8,7 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1434873-26:
(9*1)+(8*4)+(7*3)+(6*4)+(5*8)+(4*7)+(3*3)+(2*2)+(1*6)=173
173 % 10 = 3
So 1434873-26-3 is a valid CAS Registry Number.
1434873-26-3Relevant articles and documents
Potent heterocyclic ligands for human complement C3a receptor
Reid, Robert C.,Yau, Mei-Kwan,Singh, Ranee,Hamidon, Johan K.,Lim, Junxian,Stoermer, Martin J.,Fairlie, David P.
, p. 8459 - 8470 (2014/12/11)
The G-protein coupled receptor (C3aR) for human inflammatory protein complement C3a is an important component of immune, inflammatory, and metabolic diseases. A flexible compound (N2-[(2,2-diphenylethoxy)acetyl]-l-arginine, 4), known as a weak C3aR antagonist (IC50 μM), was transformed here into potent agonists (EC50 nM) of human macrophages (Ca2+ release in HMDM) by incorporating aromatic heterocycles. Antagonists were also identified. A linear correlation between binding affinity for C3aR and calculated hydrogen-bond interaction energy of the heteroatom indicated that its hydrogen-bonding capacity influenced ligand affinity and function mediated by C3aR. Hydrogen-bond accepting heterocycles (e.g., imidazole) conferred the highest affinity and agonist potency (e.g., 21, EC50 24 nM, Ca2+, HMDM) with comparable efficacy and immunostimulatory activity as that of C3a in activating human macrophages (Ca2+, IL1β, TNFα, CCL3). These potent and selective modulators of C3aR, inactivated by a C3aR antagonist, are stable C3a surrogates for interrogating roles for C3aR in physiology and disease.
