143489-45-6

Basic information

• Product Name: 2-Amino-5-hydroxypyrimidine
• Synonyms: 2-Amino-pyrimidin-5-ol;5-Pyrimidinol, 2-amino- (9CI);2-Amino-5-pyrimidinol;2-Amino-5-hydroxypyrimidine;2-Amido-5-hydroxyprimidine;2-Aminopyrimidin-5-ol, 5-Hydroxypyrimidin-2-amine;2-AMino-5-hydroxypyriMidi...
• CAS NO: 143489-45-6
• Molecular Formula: C₄H₅N₃O
• Molecular Weight: 111.1
• Product Categories: PYRIMIDINE;Heterocyclic Series;Pyrimidines;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Heterocycle-Pyrimidine series
• Mol File: 143489-45-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: >170°C (dec.)
• Boiling Point: 393.616 °C at 760 mmHg
• Flash Point: 191.853 °C
• Appearance: White to yellow/Powder or Crystalline Powder
• Density: 1.451 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 3.95±0.23(Predicted)
• CAS DataBase Reference: 2-Amino-5-hydroxypyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-hydroxypyrimidine(143489-45-6)
• EPA Substance Registry System: 2-Amino-5-hydroxypyrimidine(143489-45-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 143489-45-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C4H5N3O/c5-4-6-1-3(8)2-7-4/h1-2,8H,(H2,5,6,7)

Upstream product

• 68-35-9 sulfadiazine 

Downstream Products

• 42783-58-4 5-(benzyloxy)pyrimidin-2-amine 
• 1057667-15-8 N-(5-hydroxypyrimidin-2-yl)hexanamide 
• 102361-58-0 6-hydroxy-2-(2-methoxy-4-methylsulphinylphenyl)imidazo<1,2-a>pyrimidine 

Relevant articles and documents

Ordered mesoporous carbon as an efficient heterogeneous catalyst to activate peroxydisulfate for degradation of sulfadiazine

Catalytic potential of carbon nanomaterials in peroxydisulfate (PDS) advanced oxidation systems for degradation of antibiotics remains poorly understood. This study revealed ordered mesoporous carbon (type CMK) acted as a superior catalyst for heterogeneous degradation of sulfadiazine (SDZ) in PDS system, with a first-order reaction kinetic constant (k) and total organic carbon (TOC) mineralization efficiency of 0.06 min?1 and 59.67% ± 3.4% within 60 min, respectively. CMK catalyzed PDS system exhibited high degradation efficiencies of five other sulfonamides and three other types of antibiotics, verifying the broad-degradation capacity of antibiotics. Under neutral pH conditions, the optimal catalytic parameters were an initial SDZ concentration of 44.0 mg/L, CMK dosage of 0.07 g/L, and PDS dosage of 5.44 mmol/L, respectively. X-ray photoelectron spectroscopy and Raman spectrum analysis confirmed that the defect structure at edge of CMK and oxygen-containing functional groups on surface of CMK were major active sites, contributing to the high catalytic activity. Free radical quenching analysis revealed that both SO4?? and ?OH were generated and participated in catalytic reaction. In addition, direct electron transfer by CMK to activate PDS also occurred, further promoting catalytic performance. Configuration of SDZ molecule was optimized using density functional theory, and the possible reaction sites in SDZ molecule were calculated using Fukui function. Combining ultra-high-performance liquid chromatography (UPLC)–mass spectrometry (MS)/MS analysis, three potential degradation pathways were proposed, including the direct removal of SO2 molecules, the 14S-17 N fracture, and the 19C-20 N and 19C-27 N cleavage of the SDZ molecule. The study demonstrated that ordered mesoporous carbon could work as a feasible catalytic material for PDS advanced oxidation during removal of antibiotics from wastewater.