42783-58-4

Upstream product

• 1083329-35-4 2-N-(2,5-dimethylpyrrolo)-5-benzyloxypyrimidine 
• 143462-35-5 3-(dimethylamino)-2-(phenylmethoxy)prop-2-enal 
• 50-01-1 guanidine hydrochloride 
• 100-39-0 benzyl bromide 
• 143489-45-6 2-amino-5-hydroxypyrimidine 
• 42783-78-8 benzyloxyacetaldehyde diethyl acetal 
• 1445-39-2 2-amino-5-iodopyrimidine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1057667-18-1 N-[5-(benzyloxy)pyrimidin-2-yl]hexanamide 
• 1204139-67-2 5-(benzyloxy)-2-bromopyrimidine 
• 1204413-50-2 2-acetamido-5-benzyloxypyrimidine 
• 1622148-63-3 1-(5-benzyloxy-2-pyrimidyl)piperidine-2,6-dione 
• 1622148-62-2 1-(5-benzyloxy-2-pyrimidyl)pyrrolidine-2,5-dione 
• 1428558-29-5 di-tert-butyl (5-(benzyloxy)pyrimidin-2-yl)biscarbamate 
• 1256780-21-8 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(5-benzyloxypyrimidin-2-yl)-2-methylpyrimidin-4(3H)-on 
• 1239911-38-6 4'-{{1-[5-(benzyloxy)pyrimidin-2-yl]-4-butyl-2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl}methyl}biphenyl-2-carbonitrile 
• 1361235-68-8 N-(5-(benzyloxy)pyrimidin-2-yl)benzamide 

Relevant academic research and scientific papers

Selective NR2B Antagonists

The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, antagonists of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.

Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series

As part of our effort toward developing an effective therapeutic agent for c-Met-dependent tumors, a pyrazolone-based class II c-Met inhibitor, N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2- phenyl-2,3-dihydro-1H-pyrazole-4-c

Multifunctional antioxidants for the treatment of age-related diseases

Analogues of N,N-dimethyl-4-(pyrimidin-2-yl)piperazine-1-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS + CHL) have been synthesized. Electrospray ionization mass spectrometry studies indicate that select

Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). I

NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME

A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

NOVEL PYRIMIDINE COMPOUND HAVING DIBENZYLAMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME

A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alk

Multifunctional Compounds and Methods of Use Thereof

Compositions comprising multifunctional agents and methods of use thereof are provided.

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.