1435266-81-1

Basic information

• Product Name: (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone
• Synonyms: (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone
• CAS NO: 1435266-81-1
• Molecular Weight: 562.778
• Mol File: 1435266-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone(1435266-81-1)
• EPA Substance Registry System: (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone(1435266-81-1)

Safety Data

• Hazardous Substances Data: 1435266-81-1(Hazardous Substances Data)

Upstream product

• 1435265-49-8 tert-butyl((7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-8-yl)oxy)dimethylsilane 
• 1435266-61-7 (2-(benzyloxy)-3-methoxyphenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanol 
• 1435265-44-3 7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-8-ol 
• 2011-06-5 2-benzyloxy-3-methoxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 934-00-9 3-methocycatechol 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 1435265-53-4 C₁₈H₂₉BrO₃Si 

Downstream Products

• 1435266-31-1 (8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)(2-hydroxyphenyl)methanone 
• 1435267-03-0 (8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)(2-hydroxy-3-methoxyphenyl)methanone 

Relevant articles and documents

Multidimensional optimization of promising antitumor xanthone derivatives

A promising antitumor xanthone derivative was optimized following a multidimensional approach that involved the synthesis of 17 analogues, the study of their lipophilicity and solubility, and the evaluation of their growth inhibitory activity on four human tumor cell lines. A new synthetic route for the hit xanthone derivative was also developed and applied for the synthesis of its analogues. Among the used cell lines, the HL-60 showed to be in general more sensitive to the compounds tested, with the most potent compound having a GI50 of 5.1 μM, lower than the hit compound. Lipophilicity was evaluated by the partition coefficient (Kp) of a solute between buffer and two membrane models, namely liposomes and micelles. The compounds showed a log Kp between 3 and 5 and the two membrane models showed a good correlation (r2 = 0.916) between each other. Studies concerning relationship between solubility and structure were developed for the hit compound and 5 of its analogues.