1435269-41-2

Basic information

• Product Name: C₃₁H₃₇NO₅
• Synonyms: C₃₁H₃₇NO₅
• CAS NO: 1435269-41-2
• Molecular Weight: 503.638
• Mol File: 1435269-41-2.mol

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₇NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₇NO₅(1435269-41-2)
• EPA Substance Registry System: C₃₁H₃₇NO₅(1435269-41-2)

Safety Data

• Hazardous Substances Data: 1435269-41-2(Hazardous Substances Data)

Upstream product

• 79571-17-8 5-(methoxy)-2,2-dimethyl-2H-chromene-6-carbaldehyde 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 67015-34-3 5,6-dimethoxy-2,2-dimethyl-2H-benzopyran 
• 93109-27-4 2-(benzyloxy)-4-(diethylamino)benzaldehyde 

Relevant articles and documents

Multidimensional optimization of promising antitumor xanthone derivatives

A promising antitumor xanthone derivative was optimized following a multidimensional approach that involved the synthesis of 17 analogues, the study of their lipophilicity and solubility, and the evaluation of their growth inhibitory activity on four human tumor cell lines. A new synthetic route for the hit xanthone derivative was also developed and applied for the synthesis of its analogues. Among the used cell lines, the HL-60 showed to be in general more sensitive to the compounds tested, with the most potent compound having a GI50 of 5.1 μM, lower than the hit compound. Lipophilicity was evaluated by the partition coefficient (Kp) of a solute between buffer and two membrane models, namely liposomes and micelles. The compounds showed a log Kp between 3 and 5 and the two membrane models showed a good correlation (r2 = 0.916) between each other. Studies concerning relationship between solubility and structure were developed for the hit compound and 5 of its analogues.