67015-34-3

Basic information

• Product Name: 5,6-dimethoxy-2,2-dimethyl-2H-chromene
• CAS NO: 67015-34-3
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.2643
• Mol File: 67015-34-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 308.3°C at 760 mmHg
• Flash Point: 102.9°C
• Density: 1.063g/cm³
• Vapor Pressure: 0.00125mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: 5,6-dimethoxy-2,2-dimethyl-2H-chromene(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethoxy-2,2-dimethyl-2H-chromene(67015-34-3)
• EPA Substance Registry System: 5,6-dimethoxy-2,2-dimethyl-2H-chromene(67015-34-3)

Safety Data

• Hazardous Substances Data: 67015-34-3(Hazardous Substances Data)

Upstream product

• 113949-25-0 (E)-4-(2,3-Dimethoxy-phenyl)-2-methyl-but-3-en-2-ol 
• 1435265-81-8 6-hydroxy-5-methoxy-2,2-dimethyl-2H-benzopyran 
• 77-78-1 dimethyl sulfate 
• 79571-17-8 5-(methoxy)-2,2-dimethyl-2H-chromene-6-carbaldehyde 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 54287-99-9 5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 15854-60-1 methyl 3-(2,3-dimethoxyphenyl)propenoate 

Downstream Products

• 1435269-32-1 C₃₁H₃₇NO₅ 
• 1435269-41-2 C₃₁H₃₇NO₅ 
• 1435269-51-4 C₃₁H₃₅NO₅ 
• 1435269-63-8 C₃₁H₃₅NO₅ 
• 1435269-72-9 C₂₄H₃₁NO₅ 
• 1435269-79-6 C₂₄H₃₁NO₅ 
• 1435269-25-2 C₂₇H₂₇ClO₅ 
• 1435269-35-4 C₂₇H₂₇ClO₅ 
• 1435269-44-5 C₂₇H₂₅ClO₅ 
• 1435269-55-8 C₂₇H₂₅ClO₅ 
• 1435268-01-1 (5-chloro-2-(methoxymethoxy)phenyl)(5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-7-yl)methanol 
• 1435268-22-6 (5-chloro-2-(methoxymethoxy)phenyl)(5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-8-yl)methanol 
• 1435268-40-8 (5-chloro-2-(methoxymethoxy)phenyl)(5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-7-yl)methanone 
• 1435268-56-6 (5-chloro-2-(methoxymethoxy)phenyl)(5,6-dimethoxy-2,2-dimethyl-2H-benzopyran-8-yl)methanone 

Relevant articles and documents

Multidimensional optimization of promising antitumor xanthone derivatives

A promising antitumor xanthone derivative was optimized following a multidimensional approach that involved the synthesis of 17 analogues, the study of their lipophilicity and solubility, and the evaluation of their growth inhibitory activity on four human tumor cell lines. A new synthetic route for the hit xanthone derivative was also developed and applied for the synthesis of its analogues. Among the used cell lines, the HL-60 showed to be in general more sensitive to the compounds tested, with the most potent compound having a GI50 of 5.1 μM, lower than the hit compound. Lipophilicity was evaluated by the partition coefficient (Kp) of a solute between buffer and two membrane models, namely liposomes and micelles. The compounds showed a log Kp between 3 and 5 and the two membrane models showed a good correlation (r2 = 0.916) between each other. Studies concerning relationship between solubility and structure were developed for the hit compound and 5 of its analogues.