143536-16-7

Upstream product

• 70-11-1 α-bromoacetophenone 
• 127388-13-0 1,4-diphenyl-3-butyne-1,2-dione 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 536-74-3 phenylacetylene 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 13343-79-8 (E)-1,4-Diphenylbut-1-en-3-yne 

Downstream Products

• 177742-60-8 3-iodo-2,5-diphenylfuran 
• 955-83-9 2,5-diphenylfuran 
• 110851-33-7 2,5-diphenyl-3-(p-tolyl)furan 
• 84302-11-4 3-methyl-2,5-diphenylfuran 
• 101736-40-7 2,5-Diphenyl-3-vinyl-furan 
• 60211-80-5 2,5-diphenylfuran-3-carbaldehyde 

Relevant academic research and scientific papers

A alkynyl dione compound and its synthesis method

The invention discloses a synthetic method of an alkynyl diketone compound which is shown in a formula (II). The synthetic method comprises the following step: in methylbenzene, at 90 DEG C, carrying out a reaction to obtain the alkynyl diketone compound by using alpha hydroxy-ketone and terminal alkyne as reaction raw materials and oxygen as an oxidizing agent under the effect of a copper catalyst. The synthetic method provided by the invention has the advantages that the reaction is efficient and the yield is high; oxygen is used as the oxidizing agent; the reaction condition is mild and no strong acids or strong bases are needed; cheap metals are used for catalyzing; reaction substrates are easy to prepare; amplified reaction can be further achieved.

Oxidative coupling of terminal alkyne with α-hydroxy ketone: An expedient approach toward ynediones

An efficient and mild copper-catalyzed one-pot approach toward ynediones has been established. A variety of ynediones were constructed directly through oxidative coupling of alkyne with α-hydroxy ketone. Oxygen-oxidizing and neutral conditions in one-pot for a wide range of substrates including natural product derivatives make this transformation highly efficient and practical. On the basis of control experiments, in situ IR measurements, and isotopic labeling experiments, a plausible mechanism involving intermediate phenylglyoxal was drawn. Applications by synthesis of various heterocycles were also investigated.

A brief synthesis of β-iodofurans

5-Endo-dig iodocyclisations of alk-3-yn-1,2-diols 4, followed by in situ dehydration, lead to good yields of β-iodofurans 5, which can subsequently be converted into a wide range of derivatives 6-13, using transition metal-catalysed coupling reactions or

Asymmetric dihydroxylation of enynes

Catalytic asymmetric dihydroxylations of 1,3-enynes were studied using 9-0-(9′-phenanthryl) dihydroquinidine (PHN-DHQD) 1 and 1,4-bis-(9-0-dihydroquinidine) phthalazine (DHQD2-PHAL) 2. Terminal olefins showed moderate (38-79% ee) and trans-disu