1435459-87-2

Upstream product

• 22971-62-6 5-oxo-5-thiophen-2-yl-pentanoic acid 
• 108-55-4 glutaric anhydride, 
• 21010-06-0 5-(2-thienyl)pentanoic acid 
• 1195072-03-7 methyl 4-oxo-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-5-carboxylate 
• 1435459-21-4 C₁₁H₁₄O₃S 
• 61942-70-9 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-4-one 
• 93-05-0 N,N-diethylaniline 
• 1435459-26-9 methyl 7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate 
• 624-31-7 4-tolyl iodide 
• 229008-11-1 2-(4-methylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

CCR2 and CCR5 receptors play a key role in the development and progression of several inflammatory, cardiovascular and autoimmune diseases. Therefore, dual targeting of both receptors appeals as a promising strategy for the treatment of such complex, mult

Synthesis of thiophene-based TAK-779 analogues by C-H arylation

A rapid synthesis of thiophene-based TAK-779 analogues 1 is reported using a late-stage diversification strategy. At the end of the synthesis, the key building block 2, which was prepared in six steps from thiophene, was arylated regioselectively at the α