22971-62-6

Usage

Chemical Properties

White solid

InChI:InChI=1/C9H10O3S/c10-7(3-1-5-9(11)12)8-4-2-6-13-8/h2,4,6H,1,3,5H2,(H,11,12)

Upstream product

• 188290-36-0 thiophene 
• 108-55-4 glutaric anhydride, 
• 110-94-1 1,5-pentanedioic acid 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 2873-74-7 gloutaric dichloride 
• 1003-09-4 2-bromothiophene 
• 53715-97-2 5,5'-oxybis(5-oxopentanoic acid) 
• 13669-10-8 ethyl 2-thenoylacetate 
• 859490-26-9 2-(2-cyano-ethyl)-3-oxo-3-[2]thienyl-propionic acid ethyl ester 

Downstream Products

• 1096164-10-1 methyl 5-(2-thienyl)-5-oxopentanoate p-tosylhydrazone 
• 50683-15-3 cyclohepta[b]thiophen-4-one 
• 1435459-51-0 methyl 2-(4-tert-butylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate 
• 1435459-47-4 methyl 2-([1,1′-biphenyl]-4-yl)-7,8-dihydro-6H-[7]annulene[b]thiophene-5-carboxylate 
• 1435459-42-9 methyl 2-(4-butylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate 
• 1435459-37-2 methyl 2-(3-methylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate 
• 1435459-97-4 2-(4-butylphenyl)-N-{4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]phenyl}-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxamide 
• 1435459-92-9 2-(3-methylphenyl)-N-{4-[4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxamide 
• 1435459-87-2 N-[4-(diethylamino)phenyl]-2-(4-methylphenyl)-7,8-dihydro-6H[7]annuleno[b]thiophene-5-carboxamide 
• 1435459-75-8 2-(4-n-butylphenyl)-7,8-dihydro-6H-[7]annulene[b]thiophene-5-carboxylic acid 
• 1435459-70-3 2-(3-methylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylic acid 
• 229008-11-1 2-(4-methylphenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylic acid 
• 1435459-60-1 methyl 2-(4-nitrophenyl)-7,8-dihydro-6H-[7]annulene[b]thiophene-5-carboxylate 
• 1435459-55-4 methyl 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-6H-[7]annuleno[b]thiophene-5-carboxylate 

Relevant academic research and scientific papers

Ru-catalyzed asymmetric hydrogenation of δ-keto Weinreb amides: Enantioselective synthesis of (+)-Centrolobine

An efficient asymmetric hydrogenation of δ-keto Weinreb amides catalyzed by a Ru-Xyl-SunPhos-Daipen bifunctional catalyst has been achieved. This method afforded a series of enantio-enriched δ-hydroxy Weinreb amides in good yields (up to 93%) and enantioselectivities (up to 99%). This protocol was successfully applied to the synthesis of the key intermediate of (+)-Centrolobine.

Synthesis of thiophene-based TAK-779 analogues by C-H arylation

A rapid synthesis of thiophene-based TAK-779 analogues 1 is reported using a late-stage diversification strategy. At the end of the synthesis, the key building block 2, which was prepared in six steps from thiophene, was arylated regioselectively at the α

The total synthesis of hypodematine

Hypodematine, isolated from Hypodematium sinense Iwatsuki as an alkaloid with a new skeleton, was synthesized via nine reaction steps, in which the synthesis of 2-aryl-1-benzazocines via Beckmann rearrangement of 5H-benzocyclohepten-5-one oxime mesylate i

Quantum chemical study of the electronic structure and reactivity of complexes of 4-oxo-4-(2-thienyl)- and 4-(5-methyl-2-thienyl)-4-oxobutyryl chlorides with aluminum chloride

The geometry and electronic structures of complexes of 4-oxo-4-(2-thienyl)- and 4-oxo-4-(5-methyl-2-thienyl)butyryl chlorides with aluminum chloride, as well as the corresponding carbocations, were studied in terms of the density functional theory (DFT) u

Synthesis of γ-, δ-, and ε-lactams by asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters

Highly enantiomerically enriched γ- and δ-lactams have been prepared by a simple and very efficient procedure that involves the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)iminoesters followed by desulfinylation of the nitrogen atom and spo

Alkyl substituted [6,6]-thienyl-C61-butyric acid methyl esters: Easily accessible acceptor materials for bulk-heterojunction polymer solar cells

[6,6]-Thienyl-C61-butyric acid ester derivatives with methyl, hexyl and 2-ethylhexyl at the 5-position of thiophene ring (TCBM-Cn, n represents the number of carbon atom in the alkyl chain) were synthesized. Unlike [6,6]-phenyl-C61-b

Synthesis and cytotoxicity of novel hexahydrothieno- cycloheptapyridazinone derivatives

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2N-substituted- hexahydrothieno- cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.

Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents

A series of novel isochroman mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Analysis of structure-activity relationships led to the identification of potent compound 4n which inhibited PTP1B with IC50 value of 51.63 ± 0.91 nM. In general, high potency was associated with a dithiolane ring with a spacer of five carbons to the isochroman ring. Compound 4n has been selected for in vivo evaluation as drug candidate for anti-diabetic activity.

Substituted thiophene-2-sulfonamide antiglaucoma agents

Thiophene-2-sulfonamides with a 5-alkyl-substituent are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.