1435467-13-2

Basic information

• Product Name: 1-benzyl-5-bromo-3-methylindole
• Synonyms: 1-benzyl-5-bromo-3-methylindole
• CAS NO: 1435467-13-2
• Molecular Weight: 300.198
• Mol File: 1435467-13-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-5-bromo-3-methylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-5-bromo-3-methylindole(1435467-13-2)
• EPA Substance Registry System: 1-benzyl-5-bromo-3-methylindole(1435467-13-2)

Safety Data

• Hazardous Substances Data: 1435467-13-2(Hazardous Substances Data)

Upstream product

• 10075-48-6 5-bromo-3-methyl-1H-indole 
• 100-39-0 benzyl bromide 

Downstream Products

• 1435466-82-2 C₃₀H₃₀BrNO₅ 
• 1592481-80-5 ((4aS,9aS)-9-benzyl-6-bromo-4a-methyl-3-phenyl-4,4a,9,9a-tetrahydro-1H-pyridazino[3,4-b]indol-1-yl)(phenyl)methanone 

Relevant articles and documents

Reaction of Donor-Acceptor Cyclobutanes with Indoles: A General Protocol for the Formal Total Synthesis of (±)-Strychnine and the Total Synthesis of (±)-Akuammicine

A ligand-promoted catalytic [4+2] annulation reaction using indole derivatives and donor-acceptor (D-A) cyclobutanes is reported, thus providing an efficient and atom-economical access to versatile cyclohexa-fused indolines with excellent levels of diastereoselectivity and a broad substrate scope. In the presence of a chiral SaBOX ligand, excellent enantioselectivity was realized with up to 94 % ee. This novel synthetic method is applied as a general protocol for the total synthesis of (±)-akuammicine and the formal total synthesis of (±)-strychnine from the same common-core scaffold.