1435475-07-2

Upstream product

• 1435475-02-7 {2-[(7-chloroquinolin-4-yl)amino]phenyl}chloromethane 
• 1435475-04-9 {2-[(7-chloroquinolin-4-yl)amino]phenyl}azidomethane 
• 1435474-94-4 (2R,3S)-N-benzoylphenylisoserine aminopropyne 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 
• 86-98-6 4,7-dichloroquinoline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 49712-66-5 {2-[(7-chloroquinolin-4-yl)amino]phenyl}methanol 

Relevant academic research and scientific papers

Design, synthesis, and antiplasmodial activity of hybrid compounds based on (2 R,3 S)- N-benzoyl-3-phenylisoserine

A series of hybrid compounds based on (2R,3S)-N-benzoyl-3-phenylisoserine, artemisinin, and quinoline moieties was synthesized and tested for in vitro antiplasmodial activity against erythrocytic stages of K1 and W2 strains of Plasmodium falciparum. Two hybrid compounds incorporating (2R,3S)-N-benzoyl-3- phenylisoserine and artemisinin scaffolds were 3- to 4-fold more active than dihydroartemisinin, with nanomolar IC50 values against Plasmodium falciparum K1 strain.