1435482-84-0

Upstream product

• 1435483-35-4 methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate 
• 1214996-57-2 methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate 
• 1002102-41-1 5-(4-chlorophenyl)-4-iodo-1-phenyl-3(1H)-pyrazolecarbaldehyde 

Relevant academic research and scientific papers

Synthesis of pyrazole-fused polycyclic systems via intramolecular 1,3-dipolar cycloaddition reactions

Synthesis of a variety of pyrazole-fused systems starting from 4-iodopyrazolecarbaldehydes is described. The general strategy involves Suzuki coupling of 2-formyl aryl boronic acid with the 4-iodopyrazole derivatives generated from either Morita-Baylis-Hillman, Horner-Wadsworth-Emmons or Knoevenagel reactions followed by 1,3-dipolar cycloaddition reaction either by azomethine ylide or nitrile oxide. Interestingly, the cycloaddition reaction in substrates generated through Morita-Baylis-Hillman and Knoevenagel chemistries were diastereoselective for syn isomer. In contrast, the substrates prepared from Horner-Wadsworth-Emmons chemistry upon cycloaddition reactions afforded a mixture of syn and anti isomers in varying ratios.