1435615-83-0

Basic information

• Product Name: 6-(4-methoxyphenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine
• Synonyms: 6-(4-methoxyphenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine
• CAS NO: 1435615-83-0
• Molecular Weight: 351.213
• Mol File: 1435615-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-methoxyphenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methoxyphenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine(1435615-83-0)
• EPA Substance Registry System: 6-(4-methoxyphenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine(1435615-83-0)

Safety Data

• Hazardous Substances Data: 1435615-83-0(Hazardous Substances Data)

Upstream product

• 709631-61-8 3-iodo-6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine 
• 73183-34-3 bis(pinacol)diborane 
• 65192-28-1 2-(4-methoxyphenyl)malondialdehyde 
• 1062368-61-9 C₁₃H₁₁N₃O 

Relevant articles and documents

Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

A structure-activity relationship of the 3- and 6-positions of the pyrazolo[1,5-a]pyrimidine scaffold of the known BMP inhibitors dorsomorphin, 1, LDN-193189, 2, and DMH1, 3, led to the identification of a potent and selective compound for ALK2 versus ALK3. The potency contributions of several 3-position substituents were evaluated with subtle structural changes leading to significant changes in potency. From these studies, a novel 5-quinoline molecule was identified and designated an MLPCN probe molecule, ML347, which shows >300-fold selectivity for ALK2 and presents the community with a selective molecular probe for further biological evaluation.