14357-78-9Relevant articles and documents
PROCESS
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Page/Page column 14-15, (2019/06/11)
The present invention provides a process for the preparation of a compound of formula (2) : the process comprising reacting a compound of formula (1), a base and an alkylating agent R4-X in a nitrile-containing polar aprotic solvent to form the compound of formula (2), wherein the process is carried out at a temperature greater than 60 °C; and wherein R1, R2, R3, R4, and X are as defined in the specification.
Preparation of 6,14-Ethenomorphinane Derivatives
Marton, Janos,Szabo, Zoltan,Hosztafi, Sandor
, p. 915 - 920 (2007/10/02)
Buprenorphine (5j) and diprenorphine (5k) were synthesized from N-formyl-northebaine (1c) and N-benzyl-northebaine (1d) via new intermediates.N-cyclopropylmethyl-dihydronorthevinone 3d is a suitable compund for the synthesis of both 5j and 5k.We carried out detailed (1)H- and (13)C-NMR analysis of the new compounds. Key words: Buprenorphine; diprenorphine; rotamers, N-CHO; morphinane derivatives; alkaloids.
A procedure for preparing 3H-labeled tertiary amines. Synthesis of (3H)-6,14-endo-etheno-6,7,8,14-tetrahydrooripavine derivatives.
Lewis,Rance,Young
, p. 465 - 466 (2007/10/10)
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