72221-15-9

Upstream product

• 100-44-7 benzyl chloride 
• 2579-67-1 northebaine 
• 100-39-0 benzyl bromide 
• 2579-67-1 Northebain 

Downstream Products

• 152427-73-1 (5R,6R,7S,9R,13S,14R)-7-Acetyl-17-benzyl-4,5-epoxy-3,6-dimethoxy-6,14-ethenomorphinan 
• 152427-74-2 (5R,6R,7S,9R,13S,14R)-17-Benzyl-4,5-epoxy-7-formyl-3,6-dimethoxy-6,14-ethenomorphinan 
• 152427-77-5 (5R,6R,7S,9R,13S,14S)-7-Acetyl-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan 
• 52485-79-7 Buprenorphine 
• 14357-78-9 diprenorphine 
• 145221-12-1 N-Benzyl-7-acetoxy-norcodeinon-dimethylacetal 
• 145221-06-3 (7R)-7-Hydroxy-N-benzyl-norneopinon-dimethylacetal 
• 145221-06-3 (7S)-7-Hydroxy-N-benzyl-norneopinon-dimethylacetal 
• 145221-09-6 N-Nor-N-benzyl-neopinon-dimethylacetal 
• 145430-26-8 14,17-Cycloethano-norcodeinondimethylacetal-benzyl-hydroxyd 
• 145430-25-7 14,17-Cycloethano-norcodeinondimethylacetal-benzyl-iodid 
• 145221-15-4 (N-Benzyl-codeinondimethylacetal-14-yl)-β-tosyloxyethan 
• 145221-11-0 (N-Benzyl-norcodeinondimethylacetal-14-yl)acetamid 
• 145221-14-3 (N-Benzyl-norcodeinondimethylacetal-14-yl)-β-dimethylaminoethan 

Relevant academic research and scientific papers

14,17-Ethano-norcodeinone

A new codeinone derivative was synthesized starting with northebaine which might be of interest with regard to the question of opiate-receptor affinity in the sense of its rigidity near the anionic side of the alkaloid.Keywords. 14,17-Cycloethanocodeinone

Preparation of 6,14-Ethenomorphinane Derivatives

Buprenorphine (5j) and diprenorphine (5k) were synthesized from N-formyl-northebaine (1c) and N-benzyl-northebaine (1d) via new intermediates.N-cyclopropylmethyl-dihydronorthevinone 3d is a suitable compund for the synthesis of both 5j and 5k.We carried out detailed (1)H- and (13)C-NMR analysis of the new compounds. Key words: Buprenorphine; diprenorphine; rotamers, N-CHO; morphinane derivatives; alkaloids.