143570-97-2Relevant articles and documents
Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes
Asahi, Kaoru,Fujiwara, Shin-Ichi,Iwasaki, Takanori,Kambe, Nobuaki,Takahashi, Ryota,Tsuda, Susumu,Ueda, Ryoji,Yamauchi, Hiroki
supporting information, p. 801 - 807 (2022/02/03)
Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea
Pd(II)-Mediated C?H Activation for Cysteine Bioconjugation
Tilden, James A. R.,Lubben, Anneke T.,Reeksting, Shaun B.,Kociok-K?hn, Gabriele,Frost, Christopher G.
, (2022/01/19)
Selective bioconjugation remains a significant challenge for the synthetic chemist due to the stringent reaction conditions required by biomolecules coupled with their high degree of functionality. The current trailblazer of transition-metal mediated bioconjugation chemistry involves the use of Pd(II) complexes prepared via an oxidative addition process. Herein, the preparation of Pd(II) complexes for cysteine bioconjugation via a facile C?H activation process is reported. These complexes show bioconjugation efficiency competitive with what is seen in the current literature, with a user-friendly synthesis, common Pd(II) sources, and a more cost-effective ligand. Furthermore, these complexes need not be isolated, and still achieve high conversion efficiency and selectivity of a model peptide. These complexes also demonstrate the ability to selectively arylate a single surface cysteine residue on a model protein substrate, further demonstrating their utility.
Heteroditopic Macrobicyclic Molecular Vessels for Single Step Aerial Oxidative Transformation of Primary Alcohol Appended Cross Azobenzenes
Sarkar, Sayan,Sarkar, Piyali,Ghosh, Pradyut
, p. 6648 - 6664 (2021/05/29)
A series of oxy-ether tris-amino heteroditopic macrobicycles (L1-L4) with various cavity dimensions have been synthesized and explored for their Cu(II) catalyzed selective single step aerial oxidative cross-coupling of primary alcohol based anilines with several aromatic amines toward the formation of primary alcohol appended cross azobenzenes (POCABs). The beauty of this transformation is that the easily oxidizable benzyl/primary alcohol group remains unhampered during the course of this oxidation due to the protective oxy-ether pocket of this series of macrobicyclic vessels. Various dimensionalities of the molecular vessels have shown specific size complementary selection for substrates toward efficient syntheses of regioselective POCAB products. To establish the requirement of the three-dimensional cavity based additives, a particular catalytic reaction has been examined in the presence of macrobicycles (L2 and L3) versus macrocycles (MC1 and MC2) and tripodal acyclic (AC1 and AC2) analogous components, respectively. Subsequently, L1-L4 have been extensively utilized toward the syntheses of as many as 44 POCABs and are characterized by different spectroscopic techniques and single crystal X-ray diffraction studies.
An injectable self-healing hydrogel “Trojan Horse” for adjunctive therapy of colon cancer recurrence
Bai, Xilin
, p. 20818 - 20824 (2021/11/23)
Herein an injectable self-healing hydrogelviadynamic linkage of an imine bond based on a novel multi-aldehyde polyethylene glycol crosslinker was reported. The biocompatible crosslinker could be synthesizedviaeasy chemistry on a large scale. After cross-l
Amphiphilic Fullerene-BODIPY Photosensitizers for Targeted Photodynamic Therapy
Gedik, M. Emre,Okutan, Elif,Günayd?n, Gürcan,Gündüz, Ezel ?ztürk
supporting information, (2021/12/27)
Nanotheranostic tailor-made carriers are potent platforms for the treatment of cancer that propound a number of advantages over conventional agents for photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose-BODIPY-fullerene dyads
Radiolabeled pyridinyl analogues of dibenzylideneacetone as β-amyloid imaging probes
Cui, Xiaomei,Zhang, Xiaoyang,Peng, Cheng,Dai, Jiapei,Liu, Boli,Cui, Mengchao
, p. 44646 - 44654 (2016/06/09)
In continuation of our investigation of the dibenzylideneacetone scaffold as Aβ imaging probes, a series of derivatives containing pyridine rings with lower lipophilicity was synthesized and evaluated. Some of these probes displayed high affinities to Aβ
A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels
Poolman, Jos M.,Maity, Chandan,Boekhoven, Job,Van Der Mee, Lars,Le Sage, Vincent A.A.,Groenewold, G.J. Mirjam,Van Kasteren, Sander I.,Versluis, Frank,Van Esch, Jan H.,Eelkema, Rienk
supporting information, p. 852 - 858 (2016/02/05)
In recent years, we have developed a low molecular weight hydrogelator system that is formed in situ under ambient conditions through catalysed hydrazone formation between two individually non-gelating components. In this contribution, we describe a molecular toolbox based on this system which allows us to (1) investigate the limits of gel formation and fine-tuning of their bulk properties, (2) introduce multicolour fluorescent probes in an easy fashion to enable high-resolution imaging, and (3) chemically modify the supramolecular gel fibres through click and non-covalent chemistry, to expand the functionality of the resultant materials. In this paper we show preliminary applications of this toolbox, enabling covalent and non-covalent functionalisation of the gel network with proteins and multicolour imaging of hydrogel networks with embedded mammalian cells and their substructures. Overall, the results show that the toolbox allows for on demand gel network visualisation and functionalisation, enabling a wealth of applications in the areas of chemical biology and smart materials.
Radiosynthesis and preliminary biological evaluation of a new 18F-labeled triethylene glycol derivative of triphenylphosphonium
Tominaga, Takahiro,Ito, Hiroaki,Ishikawa, Yoichi,Iwata, Ren,Ishiwata, Kiichi,Furumoto, Shozo
, p. 117 - 123 (2016/03/12)
Delocalized lipophilic cations such as [18F]fluorobenzyltriphenylphosphonium ([18F]FBnTP) can accumulate in mitochondria and have been used in myocardial perfusion imaging (MPI). In this study, we established a simplified method for
Photoacoustic Probes for Ratiometric Imaging of Copper(II)
Li, Hao,Zhang, Pamela,Smaga, Lukas P.,Hoffman, Ryan A.,Chan, Jefferson
, p. 15628 - 15631 (2016/01/09)
Photoacoustic tomography has emerged as a promising alternative to MRI and X-ray scans in the clinical setting due to its ability to afford high-resolution images at depths in the cm range. However, its utility has not been established in the basic research arena owing to a lack of analyte-specific photoacoustic probes. To this end, we have developed acoustogenic probes for copper(II)-1 and -2 (APC-1 and APC-2, a water-soluble congener) for the chemoselective visualization of Cu(II), a metal ion which plays a crucial role in chronic neurological disorders such as Alzheimer's disease. To detect Cu(II), we have equipped both APCs with a 2-picolinic ester sensing module that is readily hydrolyzed in the presence of Cu(II) but not by other divalent metal ions. Additionally, we designed APC-1 and APC-2 explicitly for ratiometric photoacoustic imaging by using an aza-BODIPY dye scaffold exhibiting two spectrally resolved NIR absorbance bands which correspond to the 2-picolinic ester capped and uncapped phenoxide forms. The normalized ratiometric turn-on responses for APC-1 and APC-2 were 89- and 101-fold, respectively.
A [2]catenane and pretzelane based on Sn-porphyrin and crown ether
Han, Min,Zhang, Heng-Yi,Yang, Li-Xu,Ding, Zhi-Jun,Zhuang, Rui-Jie,Liu, Yu
experimental part, p. 7271 - 7277 (2012/01/13)
A [2]catenane and a pretzelane that consist of one aromatic dialkylammonium spacer, one dibenzo-24-crown-8 (DB24C8) unit, and one Sn-porphyrin dihydroxide component were synthesized. In the [2]catenane, dibenzo-24-crown-8 and the Sn-porphyrin dihydroxide
