143583-69-1Relevant academic research and scientific papers
A simple synthesis of 5-(2-Aminophenyl)-1H-pyrazoles
Janjic, Monika,Prebil, Rok,Groselj, Uros,Kralj, David,Malavasic, Crt,Golobic, Amalija,Stare, Katarina,Dahmann, Georg,Stanovnik, Branko,Svete, Jurij
, p. 1703 - 1717 (2011/10/31)
A four-step synthesis of 1-substituted 5-(2-aminophenyl)-1H-pyrazoles 5 as a novel type of histamine analogs and versatile building blocks for further transformations was developed. The synthesis starts from commercially available 2-nitroacetophenone (12), which is converted into the enamino ketone 13 as the key intermediate. Cyclization of the key intermediate 13 with monosubstituted hydrazines 14a-14l afforded the 5-(2-nitrophenyl)-1H-pyrazoles 17a-17l. Finally, catalytic hydrogenation of the nitro compounds 17a, 17c-17e, and 17g-17j furnished the title compounds 5a, 5c-5e, and 5g-5j, respectively, in good yields. As demonstrated by some further transformations, additional functionalization of compounds 17 and 5 is feasible, either by electrophilic substitution at C(4) of the pyrazole ring, or at the NH2 group. Copyright
A new route to quinolone and indole skeletones via ketone- and ester-imide cyclodehydration reactions
Kim, Guncheol,Keum, Gyochang
, p. 1979 - 1988 (2007/10/03)
Ketone-imide cyclodehydration reactions of aromatic succinimide and phthalimide (7, 8) have afforded quinolone acids (11, 12). Further transformation of the acids provided the corresponding esters (13, 14) and vinylogous urethanes (9, 10). Similarly, ester-imide cyclodehydration reactions of aromatic imide esters (19, 20) have afforded indole acids (23, 24).
Spectroscopic Studies of Benzimidazole, Quinoxaline and Quinoline Derivatives.
Alkhathlan, Hamad Z.,Al-Lohedan, Hamad A.
, p. 201 - 220 (2007/10/02)
Four fused benzimidazoles, two quinoxalines and two fused quinoline derivatives were studied with respect to their MS, NMR and IR spectra.These compounds were chosen in order to compare the effect of the size of the hetero ring and the presence of C=N and C=O on their spectral behavior.
Novel Approach to Pyrroloquinoline-1,5-diones
AlKhathlan, Hamad Z.
, p. 1984 - 1996 (2007/10/02)
The condensation of 2-aminoacetophenone with acid anhydrides is investigated.Different fused 4-quinolone derivatives were prepared in one step via this condensation.In addition different N-substituted imides were also obtained.
